| Proteasome subunit alpha type [Q4Q1R5] | |
|---|---|
| Systematic Name | LmjF.36.1600 [Leishmania major] |
| Gene Name | LMJF_36_1600 |
| Molecular Weight | 29600 Da |
| Protein Sequence Size | 263 |
| Function | |
| Charge | -7.5 |
| Isoelectric Point | 5 pH |
| Description | Proteasome subunit alpha type. |
| Subcellular Location | proteasome core complex (sensu Eukaryota)[Predict] |
| E. C. Number | 3.4.25.1 |
| Sequence | >tr|Q4Q1R5|Q4Q1R5_LEIMA Proteasome subunit alpha type - Leishmania major FKNEYDSDITTWSPTGRLFQIEYANEAVNNGSAAVGVKGRDFVVLAALKRSPVAELSSYQ EKVFEIDEHVGMSISGLVADGRVLARFLRTECMNYRYMYSHGMPMNQMADMIGEKHQRHI QFSGKRPFGVGLLLAGYDRQGPHLYQTVPSGDVYDYKATAMGVRSQASRTYLEKHFERFT DCTLDELVTHALKALASATSEGVELNVKNTTIAIVGKDTPFTIFEEESARRYLDGFKMRP EDRVAAADEEEVLQEQPLDVEE |
| DNA Sequence | >LmjF36.1600 |||proteasome alpha 1 subunit, putative|Leishmania major|chr 36|||Manual ATGTTCAAGA ACGAGTACGA TAGCGACATC ACGACCTGGA GCCCGACGGG CCGGCTCTTTCAGATCGAGT ATGCAAATGA GGCTGTCAAC AACGGCTCCG CGGCCGTTGG CGTGAAAGGGAGGGACTTCG TCGTGCTCGC CGCACTCAAG CGCAGCCCCG TCGCGGAGCT GTCCTCGTACCAAGAAAAAG TCTTCGAAAT TGACGAGCAT GTTGGCATGT CCATCTCGGG CCTCGTGGCGGACGGCCGCG TGCTTGCTCG CTTCCTGCGC ACAGAATGCA TGAACTACCG CTACATGTATAGCCATGGTA TGCCGATGAA TCAAATGGCG GACATGATCG GCGAAAAGCA CCAGCGCCACATCCAATTCA GTGGCAAGCG TCCTTTCGGC GTTGGCCTCC TGCTTGCTGG CTACGACCGTCAGGGACCAC ACCTGTACCA GACGGTGCCG TCCGGTGACG TCTACGACTA CAAGGCCACGGCGATGGGCG TGCGCTCGCA GGCGTCGCGC ACGTACTTGG AGAAGCATTT CGAGCGCTTCACCGACTGCA CCCTCGATGA GCTCGTGACG CACGCACTAA AGGCTCTCGC TTCCGCGACATCGGAGGGCG TGGAGCTGAA TGTGAAGAAC ACCACCATCG CCATCGTAGG CAAGGATACCCCCTTCACCA TCTTTGAGGA GGAGAGCGCG CGCAGGTACC TGGATGGGTT CAAGATGCGTCCAGAAGACC GCGTGGCGGC GGCGGACGAG GAGGAGGTGC TGCAGGAGCA GCCTCTGGACGTCGAGGAAT AG |
| Proteasome subunit alpha type Q4Q1R5] | |
|---|---|
| Metabolite Information | ubiquitin-dependent protein catabolism |
| Molecular Function | |
| Biochemical Pathway | |
| Regulatory Pathway | |
| KEGG Pathways | K02725 |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | proteasome alpha 1 subunit isoform 2 [Homo sapiens] | 47 | 7e-68 | 254 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| YMR314w 20S proteasome subunit (alpha6) | Saccharomyces cerevisiae | 44% | 5e-55 | 208 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| PDOC00595 | Formate--tetrahydrofolate ligase signatures | 31-34; 210-213; | PS00722 | |
| PDOC00326 | Proteasome A-type subunits signature | 6-28; | PS00388 | |
| Acylation | N-myristoylation site | 72-77; 103-108; 132-137; 203-208; | PS00008 | |
| Amidation | Amidation site | 124-127; | PS00009 | |
| Glycosylation | N-glycosylation site | 31-34; 210-213; | PS00001 | |
| Phosphorylation | Casein kinase II phosphorylation site | 59-62; 171-174; 184-187; 223-226; | PS00006 | |
| Phosphorylation | Protein kinase C phosphorylation site | 16-18; 124-126; 229-231; | PS00005 | |
| Proteasome subunit alpha type [Q4Q1R5] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 1iruT | |
| Percent Identity | 47% | |
| Target Region | 1-240 | |
| Template Region | 4-236 | |
| Domain Information | ||
|---|---|---|
| Domains | Start | End |
| Active Site Information | ||
|---|---|---|
| Residue | Active Site Number | Functional Part |
| Co-Factor | |
|---|---|
| Metal | Description |
| Ligands | |||||
|---|---|---|---|---|---|
| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| 7791-18-6 | MAGNESIUM ION | 24.305 | Mg | [Mg+2] | 1iru |
| Mutational Information | ||
|---|---|---|
| Residue | Feature | Description |
|
|
|
| Modeled Protein | Template Structure |
|
|
+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/543720/Q4Q1R5.pdb 2.0 240 = residues | | = | | Ramachandran plot: 95.8% core 4.2% allow 0.0% gener 0.0% = disall | | = | +| All Ramachandrans: 3 labelled residues (out of 238) = | | Chi1-chi2 plots: 0 labelled residues (out of 143) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | *| Residue properties: Max.deviation: 3.4 Bad contacts: = 4 | *| Bond len/angle: 6.7 Morris et al class: 1 = 1 2 | | = | | G-factors Dihedrals: 0.10 Covalent: -0.14 Overall: = 0.01 | | = | | M/c bond lengths: 99.2% within limits 0.8% highlighted = | | M/c bond angles: 94.6% within limits 5.4% highlighted = | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |