| Phosphomannomutase, putative [Q4Q1M7] | |
|---|---|
| Systematic Name | LmjF.36.1960 [Leishmania major] |
| Gene Name | PMM |
| Molecular Weight | 28101 Da |
| Protein Sequence Size | 247 |
| Function | |
| Charge | -6.5 |
| Isoelectric Point | 4.9655 pH |
| Description | Phosphomannomutase, putative (EC 3.1.3.11). |
| Subcellular Location | metabolism[Predict] |
| E. C. Number | 3.1.3.11 |
| Sequence | >tr|Q4Q1M7|Q4Q1M7_LEIMA Phosphomannomutase, putative (EC 3.1.3.11) - Leishmania major TSKVILLFDVDGTLTPPRNPETQDMKETLAKARAAGFKLGVVGGSDFAKQKEQLGDSILE DFDYVFSENGLLAYKDGTEFHRNSLLKALGNEKVVAFVKKCLHLIADLDIPVQRGTFVEF RNGMFNVSPIGRNCSQQERDEFEQLDKERHIREKLIRNLKEAFPDYPLAYSVGGQISFDV FPKGWDKTYCLQFVENDFEKIHFFGDKTSEGGNDYEIYTDCRTIGHSVKTYKDTIAILEA LLEESR |
| DNA Sequence | >LmjF36.1960 |PMM||phosphomannomutase, putative|Leishmania major|chr 36|||Manual ATGACCTCCA AGGTTATTCT TCTCTTTGAC GTCGATGGCA CCCTGACGCC GCCGCGCAACCCGGAAACGC AGGACATGAA GGAGACGCTA GCGAAAGCTC GTGCAGCTGG CTTCAAGCTTGGCGTCGTCG GTGGCTCCGA CTTCGCCAAG CAGAAGGAGC AGCTGGGCGA TTCGATTCTGGAAGACTTTG ACTATGTGTT TTCCGAGAAC GGTCTATTGG CCTACAAGGA TGGCACAGAGTTCCACCGCA ATAGCTTGCT GAAGGCTCTT GGGAACGAGA AGGTGGTGGC ATTTGTAAAGAAGTGTCTGC ACCTCATCGC CGATTTGGAC ATTCCAGTGC AGCGCGGCAC GTTTGTGGAGTTCCGCAACG GTATGTTCAA CGTGTCTCCC ATCGGCCGCA ACTGCTCGCA GCAGGAGCGTGACGAGTTCG AGCAGCTCGA CAAAGAGCGC CATATCCGTG AGAAACTGAT CAGAAACCTCAAGGAGGCCT TCCCTGACTA CCCGCTCGCC TATTCTGTAG GCGGTCAAAT CAGTTTCGACGTCTTCCCGA AGGGGTGGGA TAAGACTTAT TGTCTTCAGT TTGTCGAAAA TGACTTTGAAAAGATTCACT TTTTCGGCGA CAAGACGTCA GAGGGCGGTA ACGATTATGA GATCTACACTGATTGTCGAA CAATTGGTCA TTCTGTGAAG ACATATAAGG ACACGATTGC AATTCTTGAGGCACTCCTCG AGGAGTCACG GTGA |
| Phosphomannomutase, putative Q4Q1M7] | |
|---|---|
| Metabolite Information | mannose biosynthesis |
| Molecular Function | |
| Biochemical Pathway | |
| Regulatory Pathway | |
| KEGG Pathways | K01840 |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | phosphomannomutase 2 [Homo sapiens] | 55 | 2e-71 | 265 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| YFL045c phosphomannomutase | Saccharomyces cerevisiae | 57% | 4e-76 | 278 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| PDOC00595 | Formate--tetrahydrofolate ligase signatures | 134-137; | PS00722 | |
| Acylation | N-myristoylation site | 41-46; 45-50; 174-179; | PS00008 | |
| Glycosylation | N-glycosylation site | 134-137; | PS00001 | |
| Phosphorylation | Casein kinase II phosphorylation site | 58-61; 117-120; 136-139; 231-234; | PS00006 | |
| Phosphorylation | Protein kinase C phosphorylation site | 2-4; 228-230; 231-233; | PS00005 | |
| Phosphorylation | Tyrosine kinase phosphorylation site | 184-190; | PS00007 | |
| Sulfation | Tyrosine sulfation site | 209-223; 212-226; | PS00003 | |
| Phosphomannomutase, putative [Q4Q1M7] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 2i55C | |
| Percent Identity | 93% | |
| Target Region | 1-247 | |
| Template Region | 4-242 | |
| Domain Information | ||
|---|---|---|
| Domains | Start | End |
| Active Site Information | ||
|---|---|---|
| Residue | Active Site Number | Functional Part |
| Co-Factor | |
|---|---|
| Metal | Description |
| Ligands | |||||
|---|---|---|---|---|---|
| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| 16887-00-6 | CHLORIDE ION | 35.453 | Cl | [Cl-] | 2i55 |
| ALPHA-D-GLUCOSE 1,6-BISPHOSPHATE | 339.108 | C6 H13 O12 P2 | O=P([O-])(OC1OC(C(O)C(O)C1O)COP(=O)(O)O)O | 2i55 | |
| 7791-18-6 | MAGNESIUM ION | 24.305 | Mg | [Mg+2] | 2i55 |
| Mutational Information | ||
|---|---|---|
| Residue | Feature | Description |
|
|
|
| Modeled Protein | Template Structure |
|
|
+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/2158905/Q4Q1M7.pdb 2.0 247 = residues | | = | | Ramachandran plot: 92.7% core 7.3% allow 0.0% gener 0.0% = disall | | = | +| All Ramachandrans: 2 labelled residues (out of 245) = | | Chi1-chi2 plots: 0 labelled residues (out of 163) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | +| Residue properties: Max.deviation: 17.8 Bad contacts: = 1 | +| Bond len/angle: 4.8 Morris et al class: 1 = 1 2 | | = | | G-factors Dihedrals: 0.07 Covalent: -0.11 Overall: = 0.00 | | = | | M/c bond lengths: 99.5% within limits 0.5% highlighted = | | M/c bond angles: 94.1% within limits 5.9% highlighted = | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |