LeishBase: Leishmania Structural Database
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Chaperonin Hsp60, mitochondrial [Q4Q1M0]
Systematic NameLmjF.36.2030 [Leishmania major]
Gene NameLMJF_36_2030
Molecular Weight59318 Da
Protein Sequence Size562
Function
Charge-7
Isoelectric Point5.0827 pH
DescriptionChaperonin Hsp60, mitochondrial.
Subcellular Locationmitochondrial matrix; Mitochondrion[Predict]
E. C. Number N.A.
Sequence>tr|Q4Q1M0|Q4Q1M0_LEIMA Chaperonin Hsp60, mitochondrial - Leishmania major
LRSAVCLAGKDVRFSDKARRSMQKGVTRAVAAVATTLGPKGRNVIIEQAYGAPKITKDGV
TVAKAIEFKDRFENMGAQLVRQVCNKTNDLAGDGTTTSAVLVDSIFGEGLKCIAQGTNPI
DMKRGMDRAVEVILKSVAKQSRPIKGSEDIVQVATISANGDKEIGEMIGQAMDKVGRDGV
ITAQDGKTMATELEVVEGMSVDRGYVSPYFVTDAKAQKAELEDALVLMSAKKIQSIHSLL
PALNHVVRSGRPLLIIADDVESEALTTLIFNKLQGKLKVCCVKAPGFGDNKTAMLQDMSV
FTGAQLVGDEGTGLELDAENFDPSILGSVKKVTVTKDDTVMLNGGGDAAAVKERVELLRE
LIKNETSDYNRDKLKERLAKLSGGVAVIKVGGGSEVEVNEKKDRIEDALCSTRAAVQEGI
VAGGGTALLRASKELEALANDGSLTRDQRTGVTIVRNAIRLPAMTIAANAGKEGAVIVEK
VLEASEESTGYDAQNDKYVNMFEAGIIDPTRVVRVAISDATSVASLMMTAEAAIVELPKD
DSAAAPMGDMGGMGGMGGMGF
DNA Sequence>LmjF36.2030 |||chaperonin Hsp60, mitochondrial precursor|Leishmania major|chr 36|||Manual
ATGCTCCGCT CCGCTGTGTG CCTTGCCGGC AAGGACGTGC GCTTCAGCGA CAAGGCCCGCCGCTCCATGC AGAAGGGCGT CACTCGCGCT GTGGCTGCGG TAGCGACGAC GCTGGGGCCGAAGGGTCGCA ACGTGATCAT CGAGCAGGCC TACGGCGCGC CGAAGATCAC GAAGGATGGTGTGACCGTTG CCAAGGCGAT CGAGTTCAAG GATCGCTTCG AGAACATGGG TGCGCAGCTGGTACGCCAGG TGTGCAACAA GACGAACGAC TTGGCTGGCG ACGGCACCAC GACCTCTGCAGTGCTTGTGG ACAGCATCTT TGGCGAGGGC CTCAAGTGCA TTGCCCAGGG CACGAACCCGATCGACATGA AGCGCGGCAT GGACCGTGCT GTGGAAGTGA TCCTGAAGAG CGTTGCCAAGCAGAGCCGCC CGATCAAGGG ATCGGAGGAC ATTGTCCAGG TGGCCACCAT CTCGGCCAACGGCGATAAGG AGATCGGCGA GATGATCGGT CAGGCGATGG ACAAGGTCGG TCGCGACGGCGTCATTACGG CGCAGGACGG CAAGACGATG GCCACTGAGC TGGAGGTTGT GGAGGGCATGAGTGTGGACC GCGGCTATGT GAGCCCGTAC TTCGTGACGG ATGCGAAGGC GCAGAAGGCAGAGCTCGAGG ATGCACTGGT GCTTATGAGC GCCAAGAAGA TCCAGAGCAT TCACAGCCTTCTCCCAGCTC TCAACCACGT CGTGCGCAGC GGCCGCCCGC TTCTGATCAT CGCCGACGATGTGGAGAGCG AGGCGCTGAC AACGCTGATC TTCAACAAGT TGCAGGGCAA GCTGAAGGTGTGCTGCGTCA AGGCGCCGGG CTTCGGTGAT AACAAGACCG CCATGCTTCA AGATATGTCCGTCTTCACTG GCGCGCAGCT GGTCGGTGAT GAGGGCACGG GGCTCGAGCT GGATGCCGAAAATTTCGACC CTTCCATCCT CGGCTCTGTC AAGAAGGTGA CAGTGACGAA GGACGATACAGTGATGCTGA ACGGCGGCGG CGATGCGGCG GCGGTGAAGG AGCGCGTTGA GCTCCTCCGCGAGCTTATCA AGAACGAGAC AAGCGACTAC AATCGTGACA AGCTGAAGGA GCGTCTGGCGAAGCTGAGCG GCGGCGTGGC CGTCATCAAG GTGGGTGGCG GCTCGGAAGT GGAGGTGAACGAGAAGAAGG ACCGCATTGA GGATGCCCTG TGCTCCACTC GCGCTGCGGT GCAGGAGGGCATCGTGGCGG GCGGTGGCAC GGCTCTGCTG CGCGCCAGCA AGGAGCTGGA GGCTCTCGCCAACGACGGTT CCCTCACCCG CGATCAGCGC ACGGGTGTGA CCATCGTGCG TAATGCCATCCGTCTGCCGG CTATGACGAT TGCCGCGAAC GCTGGCAAGG AGGGTGCGGT TATTGTGGAGAAGGTGCTGG AGGCTTCCGA GGAGAGCACC GGCTACGATG CGCAGAACGA CAAGTACGTGAACATGTTCG AGGCTGGCAT CATCGACCCC ACCCGCGTCG TGCGTGTGGC CATCAGCGATGCGACGTCTG TGGCGAGTCT GATGATGACG GCCGAGGCCG CCATTGTTGA GCTGCCCAAGGACGATTCCG CTGCCGCGCC GATGGGCGAC ATGGGCGGTA TGGGCGGCAT GGGCGGCATGGGCTTCTAG
Chaperonin Hsp60, mitochondrial Q4Q1M0]
Metabolite Informationcellular protein metabolism; protein complex assembly; protein folding; protein import into mitochondrial matrix
Molecular Function
Biochemical Pathway
Regulatory Pathway
KEGG PathwaysK04077
Orthologs
Homologs GI Percent Identity Evalue Score
Homo sapienschaperonin [Homo sapiens]521e-153540
DEG Information
DEG Protein DEG Organism Percent Identity Evalue Bit Score
YLR259c heat shock protein - chaperone, mitochondrialSaccharomyces cerevisiae50%1e-146513
Post Translational Modification
PTM Type PTM Sub Type Score Modification Site Prosite ID
PDOC00268Chaperonins cpn60 signature415-426; PS00296
AcylationN-myristoylation site26-31; 60-65; 95-100; 126-131; 180-185; 345-350; 346-351; 420-425; 424-429; 552-557; 555-560; PS00008
GlycosylationN-glycosylation site86-89; 291-294; 365-368; PS00001
PhosphorylationcAMP- and cGMP-dependent protein kinase phosphorylation site331-334; PS00004
PhosphorylationCasein kinase II phosphorylation site183-186; 192-195; 313-316; 336-339; 395-398; 490-493; PS00006
PhosphorylationProtein kinase C phosphorylation site16-18; 230-232; 250-252; 329-331; 412-414; PS00005
SulfationTyrosine sulfation site485-499; PS00003
Chaperonin Hsp60, mitochondrial [Q4Q1M0]
Model Information
Template PDB ID1iokG
Percent Identity50%
Target Region9-539
Template Region2-482
Domain Information
Domains Start End
Active Site Information
Residue Active Site Number Functional Part
ASP51Sidechain
THR88Sidechain
THR89Sidechain
ASP400Sidechain
Co-Factor
Metal Description
Ligands
CAS number Name Mol. Weight Mol. Formula Smile Notation PDB Reference
Mutational Information
Residue Feature Description
Modeled Protein Template Structure
+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/484720/Q4Q1M0.pdb 2.0 531 = residues | | = | *| Ramachandran plot: 92.3% core 6.2% allow 1.1% gener 0.4% = disall | | = | *| All Ramachandrans: 21 labelled residues (out of 529) = | +| Chi1-chi2 plots: 5 labelled residues (out of 286) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | *| Residue properties: Max.deviation: 9.7 Bad contacts: = 16 | *| Bond len/angle: 11.2 Morris et al class: 1 = 1 2 | +| 1 cis-peptides = | | G-factors Dihedrals: 0.06 Covalent: -0.24 Overall: = -0.05 | | = | *| M/c bond lengths: 99.0% within limits 1.0% highlighted 2 off = graph | *| M/c bond angles: 94.5% within limits 5.5% highlighted 2 off = graph | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further.
Overlapped Structure Procheck Summary
LeishBase: Leishmania Structural Database
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