| Glucokinase 1-like protein [Q4Q1I9] | |
|---|---|
| Systematic Name | LmjF.36.2320 [Leishmania major] |
| Gene Name | LMJF_36_2320 |
| Molecular Weight | 44435 Da |
| Protein Sequence Size | 411 |
| Function | |
| Charge | 8 |
| Isoelectric Point | 8.5 pH |
| Description | Glucokinase 1-like protein (EC 2.7.1.2). |
| Subcellular Location | N.A.[Predict] |
| E. C. Number | 2.7.1.2 |
| Sequence | >tr|Q4Q1I9|Q4Q1I9_LEIMA Glucokinase 1-like protein (EC 2.7.1.2) - Leishmania major PLTDEIQLEQLAPTIKGDASWSTGPIYVVCDVGGTNARVGFARAAQHEGSGLHIIYVRFR VTKRDIRQLLEFFDEVLQHLKKNLPYRAGPFLRRVASGAVSVPGPLTNGQLAGPFSNLKG IARLADYPVELFPRGRSALLNDLEAGSYGVLALSNAGMLSDYFKVMWKGTQWDALSEGKP VGSTIGHGRCMVVAPGTGVGSSLIHYVGVSDSYVVLALECGCLSMSWCANEDSKYVQALA GYMASKARVKGLDSTVAPIWEAAANGSGLEFNYAYEKEGPKASAPLKSAPEVAKLAKAGS DPAAVAAMDRLYKNLIGLTAETTMQFLPLTCVLMGDSIVSNSFYFDNPENVKKLQARINE HTMERQLKFLSRTTFLRQVRSVNINLLGCLEFGSQLSNRADQLAPTKSNL |
| DNA Sequence | >LmjF36.2320 |||glucokinase 1-like protein|Leishmania major|chr 36|||Manual ATGCCCCTCA CAGACGAGAT CCAACTCGAG CAGCTGGCCC CCACCATCAA GGGCGACGCCTCCTGGTCCA CCGGCCCCAT CTACGTTGTG TGTGATGTTG GCGGCACGAA CGCGCGCGTCGGCTTTGCTC GAGCGGCGCA GCACGAGGGA AGCGGCCTGC ACATCATCTA TGTCCGCTTCAGGGTGACGA AGCGCGACAT CCGCCAGCTG CTCGAGTTCT TCGATGAGGT GCTGCAGCACCTGAAGAAGA ACCTGCCCTA CCGCGCTGGC CCCTTTCTGC GTCGTGTCGC GTCCGGTGCCGTGAGTGTGC CGGGACCTCT CACCAACGGA CAGCTCGCGG GCCCCTTCAG CAATCTGAAGGGCATTGCAC GGCTGGCGGA CTACCCGGTG GAGCTGTTTC CAAGGGGCCG CAGCGCGCTTCTGAACGATC TAGAGGCTGG CTCCTATGGC GTGCTGGCAC TGAGCAACGC CGGCATGCTGTCCGACTACT TCAAGGTCAT GTGGAAGGGC ACGCAGTGGG ACGCGCTGTC GGAAGGCAAGCCCGTTGGCA GCACCATCGG CCACGGCCGC TGCATGGTCG TGGCCCCCGG CACCGGCGTCGGCTCCTCTC TCATCCACTA CGTGGGTGTG TCGGACAGCT ATGTTGTGCT GGCGCTGGAGTGCGGCTGTT TGTCCATGTC TTGGTGCGCC AATGAGGACT CGAAGTACGT GCAGGCACTTGCCGGCTACA TGGCATCCAA GGCACGTGTG AAGGGCCTGG ACTCGACGGT GGCCCCCATCTGGGAGGCTG CGGCAAATGG TAGCGGGTTG GAGTTCAACT ACGCGTATGA GAAGGAGGGGCCGAAGGCAT CCGCTCCCCT CAAGTCCGCT CCCGAGGTAG CCAAGCTCGC CAAGGCTGGCAGCGACCCGG CCGCCGTGGC CGCCATGGAC CGTCTCTACA AGAACCTCAT AGGCCTCACAGCTGAGACAA CGATGCAGTT CCTGCCGCTG ACATGTGTGC TGATGGGCGA CAGCATCGTTTCCAACAGCT TTTATTTCGA TAACCCAGAG AATGTGAAGA AGCTGCAGGC TCGCATAAACGAGCACACGA TGGAGCGGCA GTTAAAGTTC TTGAGTCGCA CCACGTTCCT TCGCCAGGTGCGCAGTGTGA ACATCAACCT GCTGGGCTGC CTTGAATTTG GTAGCCAGCT CTCCAACCGGGCAGATCAGT TAGCGCCAAC CAAGTCCAAC TTGTGA |
| Glucokinase 1-like protein Q4Q1I9] | |
|---|---|
| Metabolite Information | glycolysis |
| Molecular Function | |
| Biochemical Pathway | |
| Regulatory Pathway | |
| KEGG Pathways | |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | G protein-coupled receptor 172A [Homo sapiens] | 33 | 2.3 | 31 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| kasB 3-oxoacyl-(acyl carrier protein) synthase | Mycobacterium tuberculosis H37Rv | 30% | 0.087 | 32.3 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| PDOC00595 | Formate--tetrahydrofolate ligase signatures | 266-269; | PS00722 | |
| Acylation | N-myristoylation site | 34-39; 183-188; 197-202; 199-204; 209-214; 252-257; 269-274; 300-305; 394-399; | PS00008 | |
| Glycosylation | N-glycosylation site | 266-269; | PS00001 | |
| Phosphorylation | Casein kinase II phosphorylation site | 63-66; 171-174; 268-271; 289-292; | PS00006 | |
| Phosphorylation | Protein kinase C phosphorylation site | 15-17; 63-65; 398-400; | PS00005 | |
| Sulfation | Tyrosine sulfation site | 269-283; | PS00003 | |
| Glucokinase 1-like protein [Q4Q1I9] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 2q2rB | |
| Percent Identity | 43% | |
| Target Region | 1-398 | |
| Template Region | 1-370 | |
| Domain Information | ||
|---|---|---|
| Domains | Start | End |
| Active Site Information | ||
|---|---|---|
| Residue | Active Site Number | Functional Part |
| ASP | 143 | Sidechain |
| Co-Factor | |
|---|---|
| Metal | Description |
| Ligands | |||||
|---|---|---|---|---|---|
| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| 58-64-0 | ADENOSINE-5'-DIPHOSPHATE | 427.201 | C10 H15 N5 O10 P2 | O=P(O)(O)OP(=O)(O)OCC3OC(n2cnc1c(ncnc12)N)C(O)C3O | 2q2r |
| 492-61-5 | BETA-D-GLUCOSE | 180.156 | C6 H12 O6 | OC1C(O)C(OC(O)C1O)CO | 2q2r |
| Mutational Information | ||
|---|---|---|
| Residue | Feature | Description |
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| Modeled Protein | Template Structure |
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+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/863730/Q4Q1I9.pdb 2.0 398 = residues | | = | *| Ramachandran plot: 91.7% core 7.7% allow 0.3% gener 0.3% = disall | | = | *| All Ramachandrans: 15 labelled residues (out of 395) = | +| Chi1-chi2 plots: 2 labelled residues (out of 214) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | *| Residue properties: Max.deviation: 4.0 Bad contacts: = 13 | *| Bond len/angle: 9.6 Morris et al class: 1 = 1 2 | +| 2 cis-peptides = | | G-factors Dihedrals: 0.04 Covalent: -0.32 Overall: = -0.09 | | = | | M/c bond lengths: 98.4% within limits 1.6% highlighted = | *| M/c bond angles: 93.0% within limits 7.0% highlighted 4 off = graph | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |