| Tyrosine aminotransferase, putative [Q4Q1I5] | |
|---|---|
| Systematic Name | LmjF.36.2360 [Leishmania major] |
| Gene Name | TAT |
| Molecular Weight | 49590 Da |
| Protein Sequence Size | 447 |
| Function | |
| Charge | -4.5 |
| Isoelectric Point | 5.7 pH |
| Description | Tyrosine aminotransferase, putative (EC 2.6.1.5). |
| Subcellular Location | N.A.[Predict] |
| E. C. Number | 2.6.1.5 |
| Sequence | >tr|Q4Q1I5|Q4Q1I5_LEIMA Tyrosine aminotransferase, putative (EC 2.6.1.5) - Leishmania major TIDAQAAPAAQALKASNSTGSLTEERREVEQRVAENASFRRITSSKHAQRTLQPLNNLAD NMKPSRSTKSNLRLSIGDPTVDGNLKIPEIVTEAVVDVVRSGEFNGYPPTVGADNLRQVV STYWRRFCQTKSRQEALKWENVIITSGVSQAIVLALTALCNEGDNILVCAPSFPHYKSVC ESYGIECRYYYLDPSKSWECDLRSAAGAVDRHTKAFVIINPSNPCGSNFSRAHVSDIIDF CQHHQIPLISDEIYAEMVLNNGIFTSVADFDTSVPRLILGGTAKYQVCPGWRVGWSILID PMNVAGDWAVGMERLTQLIAGVNSICQEAIARTLLKCPTECTEHIVTQLEAGAKVYARLL EHDIGISMDAPQASMFVMLKLNLSYFQDLKSDMEFYEKLLDEENVQVLPGEIFGMSGFIR ATISRPSAVLNEAVDRIIEFCERHKK |
| DNA Sequence | >LmjF36.2360 |||tyrosine aminotransferase, putative|Leishmania major|chr 36|||Manual ATGACGATTG ATGCGCAGGC CGCACCCGCG GCTCAGGCCT TGAAGGCCAG CAACTCCACGGGATCTCTTA CCGAAGAGCG CCGCGAGGTC GAGCAGCGCG TCGCTGAGAA CGCGAGTTTTCGCCGTATCA CGTCCTCGAA GCACGCCCAG CGAACCCTGC AGCCGTTGAA CAACTTGGCCGACAACATGA AGCCTTCCCG CTCCACTAAG TCGAACCTTC GTCTCTCCAT CGGCGACCCCACTGTTGACG GCAATCTCAA GATCCCCGAG ATTGTAACGG AAGCAGTGGT AGATGTTGTGCGCTCTGGCG AGTTCAACGG CTACCCGCCG ACGGTCGGGG CCGACAACTT GCGCCAGGTGGTGTCGACGT ATTGGCGCCG CTTCTGCCAG ACCAAGTCTC GTCAAGAGGC GTTGAAGTGGGAGAACGTGA TCATCACCTC CGGTGTGTCG CAGGCCATCG TGCTCGCTCT CACTGCACTGTGCAACGAGG GCGACAACAT CCTCGTGTGC GCCCCATCGT TTCCCCACTA CAAGAGCGTCTGTGAGAGCT ACGGCATCGA GTGCCGCTAC TATTACCTCG ACCCCTCGAA GAGCTGGGAGTGCGACCTCA GATCTGCGGC CGGTGCGGTG GATCGCCACA CGAAGGCATT TGTCATCATCAACCCTTCCA ACCCGTGCGG CAGCAACTTC TCCCGTGCAC ACGTAAGCGA TATCATCGATTTCTGCCAGC ATCACCAGAT CCCCCTCATC AGTGACGAAA TCTACGCTGA GATGGTGCTGAACAACGGCA TCTTCACGTC TGTCGCCGAC TTCGACACGA GCGTTCCGCG TCTCATCCTGGGCGGCACGG CCAAGTACCA GGTCTGCCCC GGCTGGCGTG TAGGCTGGTC TATCCTGATCGACCCGATGA ACGTTGCGGG AGACTGGGCT GTCGGAATGG AGCGCCTGAC CCAGCTCATCGCTGGTGTCA ACTCTATCTG CCAGGAGGCG ATTGCGCGGA CGCTGCTCAA GTGCCCTACGGAGTGCACCG AGCACATCGT CACCCAACTG GAGGCCGGCG CCAAAGTGTA CGCCCGACTGCTTGAACACG ACATTGGCAT CTCCATGGAC GCACCGCAGG CCTCCATGTT CGTGATGCTCAAGCTCAACC TCAGCTACTT TCAGGATTTG AAGTCGGATA TGGAGTTCTA CGAGAAGCTTCTGGATGAGG AGAACGTGCA GGTGCTGCCG GGTGAGATCT TTGGCATGAG TGGCTTCATTCGTGCAACGA TATCCCGCCC ATCAGCGGTG CTGAATGAGG CAGTCGACCG CATCATCGAGTTCTGTGAGC GCCACAAGAA GTAG |
| Tyrosine aminotransferase, putative Q4Q1I5] | |
|---|---|
| Metabolite Information | amino acid and derivative metabolism; biosynthesis |
| Molecular Function | |
| Biochemical Pathway | |
| Regulatory Pathway | |
| KEGG Pathways | K00815 |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | tyrosine aminotransferase [Homo sapiens] | 37 | 1e-73 | 274 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| aspC aspartate aminotransferase | Mycobacterium tuberculosis H37Rv | 24% | 2e-25 | 110 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| PDOC00595 | Formate--tetrahydrofolate ligase signatures | 18-21; 37-40; 229-232; 383-386; | PS00722 | |
| Acylation | N-myristoylation site | 148-153; 227-232; 263-268; | PS00008 | |
| Glycosylation | N-glycosylation site | 18-21; 37-40; 229-232; 383-386; | PS00001 | |
| Phosphorylation | cAMP- and cGMP-dependent protein kinase phosphorylation site | 41-44; | PS00004 | |
| Phosphorylation | Casein kinase II phosphorylation site | 22-25; 76-79; 133-136; 179-182; 267-270; 348-351; 392-395; | PS00006 | |
| Phosphorylation | Protein kinase C phosphorylation site | 39-41; 45-47; 68-70; 283-285; | PS00005 | |
| Phosphorylation | Tyrosine kinase phosphorylation site | 101-108; | PS00007 | |
| Tyrosine aminotransferase, putative [Q4Q1I5] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 1bw0B | |
| Percent Identity | 43% | |
| Target Region | 42-452 | |
| Template Region | 5-411 | |
| Domain Information | ||
|---|---|---|
| Domains | Start | End |
| Active Site Information | ||
|---|---|---|
| Residue | Active Site Number | Functional Part |
| PHE | 133 | Sidechain |
| ASP | 211 | Sidechain |
| ARG | 236 | Sidechain |
| Co-Factor | |
|---|---|
| Metal | Description |
| Pyridoxal phosphate | |
| Ligands | |||||
|---|---|---|---|---|---|
| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| Mutational Information | ||
|---|---|---|
| Residue | Feature | Description |
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| Modeled Protein | Template Structure |
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+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/1883140/Q4Q1I5.pdb 2.0 406 = residues | | = | +| Ramachandran plot: 93.1% core 6.4% allow 0.6% gener 0.0% = disall | | = | +| All Ramachandrans: 4 labelled residues (out of 404) = | +| Chi1-chi2 plots: 4 labelled residues (out of 236) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | *| Residue properties: Max.deviation: 18.7 Bad contacts: = 3 | *| Bond len/angle: 8.2 Morris et al class: 1 = 1 2 | +| 3 cis-peptides = | | G-factors Dihedrals: 0.07 Covalent: -0.15 Overall: = -0.01 | | = | | M/c bond lengths: 99.1% within limits 0.9% highlighted = | *| M/c bond angles: 94.2% within limits 5.8% highlighted 1 off = graph | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |