| Succinyl-CoA ligase [GDP-forming] beta-chain, putative [Q4Q1C4] | |
|---|---|
| Systematic Name | LmjF.36.2950 [Leishmania major] |
| Gene Name | LMJF_36_2950 |
| Molecular Weight | 44188 Da |
| Protein Sequence Size | 413 |
| Function | |
| Charge | 2.5 |
| Isoelectric Point | 6.9 pH |
| Description | Succinyl-CoA ligase [GDP-forming] beta-chain, putative (EC 6.2.1.5). |
| Subcellular Location | Mitochondrion[Predict] |
| E. C. Number | 6.2.1.5 |
| Sequence | >tr|Q4Q1C4|Q4Q1C4_LEIMA Succinyl-CoA ligase [GDP-forming] beta-chain, putative (EC 6.2.1.5) - Leishmania major FRFGRLCTPKAASVQRRFLNIHEYQSKQIIKDNGGRVEFGIACKTIEEVEAACAKIKTEK KVVKSQILAGGRGKGVFKDGFQGGVHVCDSAAAAVEAAKHMLGNTLVTKQTGPKGQLVNT LYVTEAVAGIKRELYLSLILDRKSASPMFIGSAEGGMSIEELAKTHPEKIKTMKVNVAEG VDHDAAVAYAKELGFAGETTERAAEQIKALYNIGKSKDCTMVEINPFVELENGDVMEIDA KLSFDDNAAFRQRGIFALEDQTQIDSKEVLAKKHDLNYIALDGNVGCLVNGAGLAMATMD TISLHGGSAANFLDAGGSASEEQIVAAFKIITGDSNVKSILVNIFGGIMHCDVIAQGVVN ASKALNTTIPIVVRLCGTNEQRGKEIIRNSGLVIHPVEDFDSAARKAVELAK |
| DNA Sequence | >LmjF36.2950 |||succinyl-CoA ligase [GDP-forming] beta-chain, putative|Leishmania major|chr 36|||Manual ATGTTCCGCT TTGGTCGCTT GTGCACCCCC AAAGCTGCCA GCGTGCAGCG CCGCTTCCTGAACATCCATG AGTACCAGTC CAAGCAGATC ATTAAGGACA ACGGCGGCAG GGTGGAGTTCGGTATTGCAT GCAAGACGAT CGAGGAGGTC GAGGCCGCGT GCGCCAAGAT CAAGACGGAGAAGAAGGTCG TGAAGTCTCA GATCTTGGCC GGTGGTCGCG GTAAGGGTGT ATTCAAAGATGGCTTCCAGG GTGGTGTGCA CGTGTGCGAC AGCGCCGCTG CCGCCGTCGA GGCTGCCAAGCACATGCTCG GTAACACGCT GGTGACGAAG CAGACCGGTC CCAAGGGCCA GCTGGTGAACACGCTGTACG TCACGGAGGC CGTCGCGGGC ATCAAGCGCG AGCTCTACCT TTCCCTCATCCTCGACCGAA AGAGCGCGTC GCCCATGTTC ATCGGTAGCG CCGAGGGCGG TATGAGCATCGAGGAGCTCG CCAAGACCCA CCCGGAAAAG ATCAAGACCA TGAAGGTCAA CGTCGCTGAGGGTGTGGACC ACGACGCGGC TGTGGCGTAC GCCAAGGAGC TCGGCTTCGC AGGTGAGACGACGGAGCGCG CGGCAGAGCA AATCAAAGCC CTCTACAATA TCGGCAAGTC GAAGGACTGCACCATGGTGG AGATTAATCC ATTCGTTGAG CTCGAAAACG GTGATGTGAT GGAGATCGACGCCAAGCTCA GCTTTGACGA CAACGCCGCC TTCCGCCAGA GGGGTATCTT CGCCCTGGAGGATCAGACCC AGATCGATAG CAAGGAAGTG CTCGCCAAGA AGCACGATCT GAACTACATCGCTCTTGATG GCAATGTCGG CTGTCTTGTG AATGGCGCTG GTCTGGCCAT GGCCACCATGGACACCATTT CTCTGCACGG CGGCAGCGCG GCCAACTTCC TCGACGCTGG TGGTAGCGCCTCCGAGGAGC AGATTGTGGC TGCCTTCAAG ATCATCACGG GTGATTCGAA CGTGAAGAGCATCCTGGTTA ACATCTTCGG TGGTATCATG CACTGCGATG TCATAGCGCA AGGTGTCGTGAACGCCTCCA AGGCGCTCAA CACCACCATC CCGATCGTGG TGCGCCTTTG CGGCACTAACGAGCAGCGCG GCAAGGAGAT CATCCGCAAC AGTGGCCTCG TCATCCACCC CGTCGAAGACTTCGATTCCG CTGCCCGCAA GGCGGTAGAG CTTGCCAAGT AG |
| Succinyl-CoA ligase [GDP-forming] beta-chain, putative Q4Q1C4] | |
|---|---|
| Metabolite Information | metabolism; tricarboxylic acid cycle |
| Molecular Function | |
| Biochemical Pathway | |
| Regulatory Pathway | |
| KEGG Pathways | K01903 |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | succinate-CoA ligase, ADP-forming, beta subunit [Homo sapiens] | 46 | 1e-98 | 357 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| sucC succinyl-CoA synthetase subunit beta | Mycobacterium tuberculosis H37Rv | 38% | 1e-66 | 247 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| PDOC00335 | ATP-citrate lyase / succinyl-CoA ligases signatures | 284-308; | PS01217 | |
| PDOC00017 | ATP/GTP-binding site motif A (P-loop) | 210-217; | PS00017 | |
| PDOC00595 | Formate--tetrahydrofolate ligase signatures | 361-364; 367-370; | PS00722 | |
| Acylation | N-myristoylation site | 85-90; 116-121; 152-157; 284-289; 287-292; 292-297; 294-299; 307-312; 308-313; 317-322; 348-353; 358-363; | PS00008 | |
| Glycosylation | N-glycosylation site | 361-364; 367-370; | PS00001 | |
| Phosphorylation | Casein kinase II phosphorylation site | 46-49; 159-162; 166-169; 221-224; 244-247; 263-266; 319-322; | PS00006 | |
| Phosphorylation | Protein kinase C phosphorylation site | 9-11; 59-61; 173-175; 201-203; | PS00005 | |
| Phosphorylation | Tyrosine kinase phosphorylation site | 273-279; | PS00007 | |
| Succinyl-CoA ligase [GDP-forming] beta-chain, putative [Q4Q1C4] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 2fppB | |
| Percent Identity | 46% | |
| Target Region | 12-413 | |
| Template Region | 2-392 | |
| Domain Information | ||
|---|---|---|
| Domains | Start | End |
| Active Site Information | ||
|---|---|---|
| Residue | Active Site Number | Functional Part |
| TYR | 116 | Unknown |
| GLU | 204 | Unknown |
| Co-Factor | |
|---|---|
| Metal | Description |
| Ligands | |||||
|---|---|---|---|---|---|
| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| 16887-00-6 | CHLORIDE ION | 35.453 | Cl | [Cl-] | 2fpp |
| 14808-79-8 | SULFATE ION | 96.063 | O4 S | [O-]S([O-])(=O)=O | 2fpp |
| Mutational Information | ||
|---|---|---|
| Residue | Feature | Description |
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| Modeled Protein | Template Structure |
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+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/4238235/Q4Q1C4.pdb 2.0 393 = residues | | = | +| Ramachandran plot: 93.4% core 6.3% allow 0.3% gener 0.0% = disall | | = | +| All Ramachandrans: 5 labelled residues (out of 391) = | +| Chi1-chi2 plots: 2 labelled residues (out of 223) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | *| Residue properties: Max.deviation: 3.3 Bad contacts: = 3 | *| Bond len/angle: 5.5 Morris et al class: 1 = 1 2 | +| 1 cis-peptides = | | G-factors Dihedrals: 0.11 Covalent: -0.09 Overall: = 0.03 | | = | | M/c bond lengths: 99.6% within limits 0.4% highlighted = | | M/c bond angles: 95.2% within limits 4.8% highlighted = | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |