| Fibrillarin [Q4Q1B2] | |
|---|---|
| Systematic Name | LmjF.36.3070 [Leishmania major] |
| Gene Name | LMJF_36_3070 |
| Molecular Weight | 25787 Da |
| Protein Sequence Size | 234 |
| Function | |
| Charge | 9 |
| Isoelectric Point | 9.4204 pH |
| Description | Fibrillarin. |
| Subcellular Location | nucleus[Predict] |
| E. C. Number | N.A. |
| Sequence | >tr|Q4Q1B2|Q4Q1B2_LEIMA Fibrillarin - Leishmania major LHPGVFISKAKTDSLCTLNMVPGISVYGEKRIELGATQGGDDKKEYRLWNPYRSKLASAI YAGVSSIHMGPGSKVLYLGGATGTTVSHVSDLVGPEGMVYAVEFSHRVGRDLVEMSKRRP NIVPIVEDARYPMKYRMLVPMVDCIFMDVAQPDQARILALNAQAFLQNGGHYVISIKANC IDSTLEAPVVIASELNKLKKDKLKPLEQVSLEPFERDHAVVVGVYRPVKKSKQ |
| DNA Sequence | >LmjF36.3070 |||fibrillarin|Leishmania major|chr 36|||Manual ATGCTGCATC CTGGCGTGTT CATTTCCAAG GCCAAGACCG ACTCTCTTTG CACGCTGAACATGGTGCCCG GTATTTCCGT TTATGGCGAG AAGCGTATCG AGCTGGGTGC AACGCAGGGAGGTGATGATA AGAAGGAGTA CCGTCTGTGG AACCCCTACC GCTCGAAGCT GGCCTCCGCCATCTACGCTG GTGTGAGTAG CATTCACATG GGTCCCGGCT CGAAGGTACT GTATCTCGGCGGTGCAACGG GTACCACCGT CAGCCACGTG AGCGACCTTG TGGGTCCGGA GGGCATGGTGTATGCTGTGG AGTTCTCGCA CCGTGTAGGC CGCGATTTAG TGGAGATGTC GAAGCGCCGCCCGAATATTG TGCCCATTGT TGAGGATGCC CGCTACCCCA TGAAGTACCG CATGCTTGTGCCGATGGTGG ATTGCATTTT CATGGATGTC GCCCAGCCAG ACCAGGCGCG AATTCTTGCACTCAACGCAC AGGCTTTTCT GCAGAACGGT GGTCACTATG TGATCTCTAT CAAGGCTAACTGCATCGACT CTACCCTGGA GGCCCCTGTA GTGATCGCGT CTGAGCTGAA CAAGCTGAAGAAGGACAAGC TGAAGCCACT GGAGCAAGTG TCTCTTGAGC CGTTCGAGCG CGATCACGCTGTAGTTGTTG GCGTGTACCG CCCTGTCAAG AAGTCGAAGC AATGA |
| Fibrillarin Q4Q1B2] | |
|---|---|
| Metabolite Information | rRNA processing |
| Molecular Function | |
| Biochemical Pathway | |
| Regulatory Pathway | |
| KEGG Pathways | |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | fibrillarin [Homo sapiens] | 65 | 9e-85 | 310 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| YDL014w fibrillarin | Saccharomyces cerevisiae | 60% | 3e-76 | 278 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| PDOC00489 | Fibrillarin signature | 98-112; | PS00566 | |
| Acylation | N-myristoylation site | 5-10; 36-41; 80-85; 81-86; 84-89; 98-103; | PS00008 | |
| Phosphorylation | Casein kinase II phosphorylation site | 184-187; | PS00006 | |
| Phosphorylation | Protein kinase C phosphorylation site | 106-108; 117-119; 176-178; | PS00005 | |
| Fibrillarin [Q4Q1B2] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 2ipxA | |
| Percent Identity | 66% | |
| Target Region | 1-234 | |
| Template Region | 88-220 | |
| Domain Information | ||
|---|---|---|
| Domains | Start | End |
| Active Site Information | ||
|---|---|---|
| Residue | Active Site Number | Functional Part |
| Co-Factor | |
|---|---|
| Metal | Description |
| Ligands | |||||
|---|---|---|---|---|---|
| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| 17787-72-3 | CALCIUM ION | 40.078 | Ca | [Ca+2] | 2ipx |
| 5'-DEOXY-5'-METHYLTHIOADENOSINE | 297.334 | C11 H15 N5 O3 S | n2c1c(ncnc1n(c2)C3OC(C(O)C3O)CSC)N | 2ipx | |
| Mutational Information | ||
|---|---|---|
| Residue | Feature | Description |
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| Modeled Protein | Template Structure |
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+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/2818548/Q4Q1B2.pdb 2.0 234 = residues | | = | +| Ramachandran plot: 92.5% core 5.5% allow 2.0% gener 0.0% = disall | | = | +| All Ramachandrans: 5 labelled residues (out of 232) = | | Chi1-chi2 plots: 0 labelled residues (out of 132) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | | Residue properties: Max.deviation: 2.9 Bad contacts: = 3 | +| Bond len/angle: 4.1 Morris et al class: 1 = 1 2 | | = | | G-factors Dihedrals: 0.08 Covalent: -0.13 Overall: = 0.00 | | = | | M/c bond lengths: 99.5% within limits 0.5% highlighted = | | M/c bond angles: 93.1% within limits 6.9% highlighted = | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |