| 14-3-3 protein-like protein [Q4Q198] | |
|---|---|
| Systematic Name | LmjF.36.3210 [Leishmania major] |
| Gene Name | Lm |
| Molecular Weight | 29688 Da |
| Protein Sequence Size | 258 |
| Function | |
| Charge | -13 |
| Isoelectric Point | 4.5192 pH |
| Description | 14-3-3 protein-like protein. |
| Subcellular Location | nucleus[Predict] |
| E. C. Number | N.A. |
| Sequence | >tr|Q4Q198|Q4Q198_LEIMA 14-3-3 protein-like protein - Leishmania major TETIKWKNVAIQDEVVPRPSDIKLPDDLAELIYMAKLAEEAERFDEMLLCIRKYVRLNSE LDTEERNLLSVAYKNVITPRRNAWRVITSIESRENAKENSATLPFVVNMRRELEAELSPL CDDLLSLLDTYLIPAAQGGEAKVFYLKMKGDYHRYYAEIDSGDGQRQAALSAYQKATDVA NSSLAPTHPIRLGLALNFSVFYYEIMKEHEKGFQLARQAYDEAVTELETLDDEAYHESNT IVRLLRENLNLWTDDQL |
| DNA Sequence | >LmjF36.3210 |||14-3-3 protein-like protein|Leishmania major|chr 36|||Manual ATGACGGAGA CGATCAAGTG GAAAAACGTC GCCATCCAAG ACGAGGTGGT CCCCAGGCCGAGTGACATCA AGCTTCCCGA TGACCTCGCC GAACTCATCT ACATGGCCAA GCTGGCCGAGGAAGCAGAGC GCTTTGACGA AATGCTGCTC TGCATTCGCA AGTATGTGCG GCTGAACAGTGAGCTCGACA CGGAGGAGCG TAACCTGCTG TCGGTGGCGT ACAAGAACGT GATCACGCCGCGCCGCAACG CTTGGCGCGT CATTACCTCT ATCGAGAGTC GTGAGAACGC CAAGGAGAACAGCGCCACAC TGCCCTTCGT GGTGAACATG CGGAGGGAGT TAGAGGCAGA GCTCTCCCCGCTCTGCGACG ACCTGCTCAG TCTTCTCGAC ACCTACCTCA TCCCGGCCGC CCAGGGCGGCGAGGCGAAGG TTTTTTACCT CAAGATGAAG GGCGACTACC ACCGCTACTA CGCCGAGATCGACTCCGGCG ATGGACAGCG GCAGGCAGCC TTGAGCGCCT ACCAAAAGGC AACGGACGTCGCGAACTCGT CCCTTGCTCC GACGCACCCT ATCCGCCTCG GTCTGGCGCT GAACTTCTCTGTGTTTTACT ACGAAATCAT GAAGGAGCAC GAGAAGGGCT TCCAGCTGGC TCGTCAGGCTTACGACGAGG CCGTGACGGA GCTCGAGACG CTCGACGACG AGGCCTACCA CGAGTCCAACACCATTGTGC GCCTCCTCCG TGAGAACCTC AACTTGTGGA CGGATGACCA GCTGTAA |
| 14-3-3 protein-like protein Q4Q198] | |
|---|---|
| Metabolite Information | Ras protein signal transduction |
| Molecular Function | |
| Biochemical Pathway | |
| Regulatory Pathway | |
| KEGG Pathways | K06630 |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | tyrosine 3/tryptophan 5 -monooxygenase activation protein, epsilon polypeptide [Homo sapiens] | 51 | 2e-62 | 236 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| YKL203c phosphatidylinositol 3-kinase | Saccharomyces cerevisiae | 37% | 3.4 | 26.2 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| PDOC00633 | 14-3-3 proteins signatures | 67-77; | PS00796 | |
| PDOC00595 | Formate--tetrahydrofolate ligase signatures | 182-185; 198-201; | PS00722 | |
| Acylation | N-myristoylation site | 165-170; 194-199; | PS00008 | |
| Glycosylation | N-glycosylation site | 182-185; 198-201; | PS00001 | |
| Phosphorylation | Casein kinase II phosphorylation site | 60-63; 89-92; 127-130; 226-229; 230-233; | PS00006 | |
| Phosphorylation | Protein kinase C phosphorylation site | 4-6; 79-81; | PS00005 | |
| Phosphorylation | Tyrosine kinase phosphorylation site | 148-156; | PS00007 | |
| Sulfation | Tyrosine sulfation site | 229-243; | PS00003 | |
| 14-3-3 protein-like protein [Q4Q198] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 2br9A | |
| Percent Identity | 51% | |
| Target Region | 28-258 | |
| Template Region | 3-230 | |
| Domain Information | ||
|---|---|---|
| Domains | Start | End |
| Active Site Information | ||
|---|---|---|
| Residue | Active Site Number | Functional Part |
| Co-Factor | |
|---|---|
| Metal | Description |
| Ligands | |||||
|---|---|---|---|---|---|
| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| Mutational Information | ||
|---|---|---|
| Residue | Feature | Description |
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| Modeled Protein | Template Structure |
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+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/1073367/Q4Q198.pdb 2.0 231 = residues | | = | | Ramachandran plot: 97.2% core 2.8% allow 0.0% gener 0.0% = disall | | = | +| All Ramachandrans: 1 labelled residues (out of 229) = | +| Chi1-chi2 plots: 2 labelled residues (out of 157) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | *| Residue properties: Max.deviation: 3.0 Bad contacts: = 1 | *| Bond len/angle: 8.9 Morris et al class: 1 = 1 1 | | = | | G-factors Dihedrals: 0.30 Covalent: -0.09 Overall: = 0.15 | | = | | M/c bond lengths: 99.7% within limits 0.3% highlighted = | *| M/c bond angles: 95.5% within limits 4.5% highlighted 1 off = graph | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |