| ADP ribosylation factor 3, putative [Q4Q0D7] | |
|---|---|
| Systematic Name | LmjF.36.6230 [Leishmania major] |
| Gene Name | ARL-3B |
| Molecular Weight | 20004 Da |
| Protein Sequence Size | 178 |
| Function | |
| Charge | 2.5 |
| Isoelectric Point | 8.4 pH |
| Description | ADP ribosylation factor 3, putative. |
| Subcellular Location | N.A.[Predict] |
| E. C. Number | N.A. |
| Sequence | >tr|Q4Q0D7|Q4Q0D7_LEIMA ADP ribosylation factor 3, putative - Leishmania major GILDFLMRIRPTSRPAGILILGLDNAGKTSILRQLSDEDISHVASTQGFQIKKLVTGGIK INVWDMGGQRAARYYWRQYFKEADVVIYVIDAADPRRIREARRELEHLLEEEKVAGVPML VFANKQDLLGAMPVEEVSVALNLTDLRDRSWHIQACSAKTGEGLDEGISWAVKQVKK |
| DNA Sequence | >LmjF36.6230 |ARL-3B||ADP ribosylation factor 3, putative|Leishmania major|chr 36|||Manual ATGGGCATCT TAGACTTCTT GATGCGGATC CGTCCCACGA GTAGACCGGC GGGTATTTTGATTCTAGGTC TCGACAACGC TGGCAAGACA AGCATCCTGC GCCAGCTCAG TGACGAGGATATCTCGCACG TCGCGTCCAC GCAGGGATTT CAGATAAAGA AGCTCGTTAC CGGCGGAATCAAGATCAACG TTTGGGATAT GGGAGGCCAG CGCGCGGCGC GCTACTACTG GCGACAGTACTTCAAAGAGG CGGACGTCGT CATCTACGTC ATAGATGCGG CTGATCCTCG GCGCATCCGCGAGGCACGTC GTGAGCTGGA ACACCTGCTG GAGGAAGAGA AGGTGGCGGG GGTGCCAATGCTTGTCTTCG CGAACAAGCA GGATTTGCTG GGTGCAATGC CGGTAGAAGA GGTCTCCGTAGCACTCAACC TGACAGATTT GCGAGACCGA AGCTGGCACA TTCAGGCGTG CTCAGCCAAGACAGGCGAGG GGCTGGATGA GGGCATCAGC TGGGCCGTGA AGCAGGTGAA GAAGTGA |
| ADP ribosylation factor 3, putative Q4Q0D7] | |
|---|---|
| Metabolite Information | intracellular protein transport; small GTPase mediated signal transduction |
| Molecular Function | |
| Biochemical Pathway | |
| Regulatory Pathway | |
| KEGG Pathways | K07944 |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | ADP-ribosylation factor-like 3 [Homo sapiens] | 49 | 1e-46 | 182 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| YPL218w GTP-binding protein of the ARF family | Saccharomyces cerevisiae | 28% | 2e-17 | 82.4 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| PDOC00017 | ATP/GTP-binding site motif A (P-loop) | 23-30; | PS00017 | |
| PDOC00595 | Formate--tetrahydrofolate ligase signatures | 143-146; | PS00722 | |
| Acylation | N-myristoylation site | 23-28; 59-64; 68-73; 69-74; 164-169; 168-173; | PS00008 | |
| Glycosylation | N-glycosylation site | 143-146; | PS00001 | |
| Phosphorylation | Casein kinase II phosphorylation site | 37-40; | PS00006 | |
| Phosphorylation | Protein kinase C phosphorylation site | 13-15; 158-160; | PS00005 | |
| Phosphorylation | Tyrosine kinase phosphorylation site | 37-40; | PS00007 | |
| ADP ribosylation factor 3, putative [Q4Q0D7] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 1fzqA | |
| Percent Identity | 49% | |
| Target Region | 1-176 | |
| Template Region | 2-176 | |
| Domain Information | ||
|---|---|---|
| Domains | Start | End |
| Active Site Information | ||
|---|---|---|
| Residue | Active Site Number | Functional Part |
| GLN | 70 | Sidechain |
| Co-Factor | |
|---|---|
| Metal | Description |
| Ligands | |||||
|---|---|---|---|---|---|
| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| 146-91-8 | GUANOSINE-5'-DIPHOSPHATE | 443.201 | C10 H15 N5 O11 P2 | O=P(O)(O)OP(=O)(O)OCC3OC(n2cnc1c2N=C(N)NC1=O)C(O)C3O | 1fzq |
| 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | 195.237 | C6 H13 N O4 S | [O-]S(=O)(=O)CC[NH+]1CCOCC1 | 1fzq | |
| 14798-03-9 | AMMONIUM ION | 18.038 | H4 N | [NH4+] | 1fzq |
| 14808-79-8 | SULFATE ION | 96.063 | O4 S   | [O-]S([O-])(=O)=O | 1fzq |
| Mutational Information | ||
|---|---|---|
| Residue | Feature | Description |
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| Modeled Protein | Template Structure |
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+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/2276550/Q4Q0D7.pdb 2.0 178 = residues | | = | | Ramachandran plot: 94.9% core 5.1% allow 0.0% gener 0.0% = disall | | = | | All Ramachandrans: 0 labelled residues (out of 176) = | | Chi1-chi2 plots: 0 labelled residues (out of 113) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | | Residue properties: Max.deviation: 2.6 Bad contacts: = 0 | +| Bond len/angle: 4.6 Morris et al class: 1 = 1 2 | | = | | G-factors Dihedrals: 0.14 Covalent: -0.05 Overall: = 0.07 | | = | | M/c bond lengths:100.0% within limits 0.0% highlighted = | | M/c bond angles: 96.0% within limits 4.0% highlighted = | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |