| Prolyl oligopeptidase, putative [Q4Q080] | |
|---|---|
| Systematic Name | LmjF.36.6750 [Leishmania major] |
| Gene Name | LMJF_36_6750 |
| Molecular Weight | 78248 Da |
| Protein Sequence Size | 697 |
| Function | |
| Charge | -8.5 |
| Isoelectric Point | 5.8 pH |
| Description | Prolyl oligopeptidase, putative (Serine peptidase clan sc, family s9a, putative) (EC 3.4.21.26). |
| Subcellular Location | cytoplasm; nucleus[Predict] |
| E. C. Number | 3.4.21.26 |
| Sequence | >tr|Q4Q080|Q4Q080_LEIMA Prolyl oligopeptidase, putative (Serine peptidase clan sc, family s9a, putative) (EC 3.4.21.26) - Leishmania major. KSLYPVVRRAATTYQLHGRTIPEPYDYLEDPCHAETKEFVRQQNEAFEAYMKSSNEVRDK IVERVTAMLNYARTSNPSLHAGKYYYQYNTGLQNQSVIMQATSLKDDNPTVFLDPNTLSA DGTTALKAHAWSENEEFFAYSLSDKGSDWQYIQVLNAETGEQLPDKLNWAKFSGISWWKN DGFFYQRYPELSEDADKGAETDSAQNQYVCFHKVGTAQSEDLLILQVPEHPQWILAAEVT DDHEYLVICVMNGCEPNNLIWIAKLPTTYEELQKPLEFKKVVNTFVGQYSYVGNEGKMFY MTSTKDASRKKIISINLETTEEKDVVAEKESVLNRAALVKDTLIMVYLEDVKDVMYYRKL HGETEMKKLDLPLGTITSLFADYKKDFVSFKVSSFMLPGRSYVMDINNPQGSLTVYKDDV VDGLNVEDYVTVQHFYQSADGTKIPMFIVHKKGSLSTKSPVMLYGYGGFGVSLTPSFSPS RIVFLQHLGGVLAIPNIRGGNEYGQSWHDAGRLTKKQNCFTDFVSAAKYLHSNKIGSPAT TAIMGGSNGGLLVAACANQAPDEFSCVVCQVGVLDMFKFHKFTIGHAWISDYGNPDEEED FRVLEKYSPIHNVRAGVKYPAILVVTGDHDDRVVPLHSLKYVATLQHANPELGGPFLARV EVAAGHGFGKPTSKIITETSDMYAFMAKNIGATWHD |
| DNA Sequence | >LmjF36.6750 |||prolyl oligopeptidase, putative|Leishmania major|chr 36|||Manual ATGAAGTCCC TCTACCCAGT GGTCCGCCGT GCGGCTACGA CCTACCAGCT GCACGGCCGCACAATCCCGG AGCCGTACGA CTACCTCGAG GACCCATGTC ATGCCGAGAC GAAGGAGTTCGTGCGGCAGC AAAACGAGGC ATTCGAGGCG TACATGAAGT CCTCCAACGA GGTCCGAGACAAGATAGTGG AGCGAGTGAC GGCGATGCTC AACTACGCGC GCACAAGTAA CCCGAGTCTGCACGCTGGCA AGTACTACTA TCAATACAAC ACCGGTCTGC AAAACCAGAG CGTCATCATGCAGGCGACGT CTCTCAAGGA CGACAATCCG ACTGTCTTTC TCGACCCAAA CACTCTTAGTGCCGACGGCA CCACTGCTCT CAAGGCGCAC GCTTGGAGCG AGAACGAGGA GTTCTTTGCCTACAGCCTCA GCGACAAGGG AAGCGATTGG CAGTACATCC AGGTACTCAA CGCGGAGACAGGGGAACAAC TTCCGGACAA GCTGAACTGG GCGAAGTTTT CGGGCATCTC GTGGTGGAAAAACGACGGCT TCTTCTACCA GCGCTATCCC GAGCTCAGCG AGGACGCCGA CAAGGGCGCCGAGACGGACT CGGCGCAGAA TCAGTACGTG TGCTTCCACA AGGTCGGGAC CGCGCAGTCGGAGGATTTGC TCATTCTGCA GGTGCCCGAG CATCCCCAGT GGATCTTGGC GGCCGAGGTGACGGATGACC ACGAGTACCT CGTCATCTGC GTCATGAACG GGTGTGAACC GAACAACCTTATTTGGATCG CGAAGCTGCC GACCACCTAC GAGGAGTTGC AGAAGCCGCT GGAGTTCAAGAAGGTGGTGA ACACATTCGT CGGCCAGTAC AGCTACGTCG GCAACGAGGG TAAGATGTTTTACATGACGA GCACCAAGGA TGCTTCGCGC AAAAAGATCA TTTCCATTAA CCTGGAAACGACCGAGGAAA AGGATGTCGT CGCTGAGAAG GAGTCAGTGC TGAACCGTGC TGCCCTTGTGAAAGACACGC TGATCATGGT GTATCTTGAG GACGTCAAGG ACGTGATGTA CTACCGCAAGCTGCACGGGG AGACGGAGAT GAAGAAATTG GACCTGCCGC TCGGCACCAT CACGTCCTTATTTGCTGACT ATAAGAAGGA CTTTGTCTCC TTCAAGGTCT CCTCGTTCAT GTTGCCAGGTCGCTCCTATG TCATGGACAT CAACAACCCG CAGGGCTCGC TGACGGTCTA CAAGGACGACGTAGTGGACG GCCTCAACGT CGAAGACTAT GTCACTGTGC AACACTTTTA CCAATCTGCTGATGGCACGA AGATTCCGAT GTTTATTGTG CACAAGAAGG GGTCCTTGTC CACCAAATCACCGGTCATGC TGTACGGCTA CGGTGGTTTT GGCGTTTCGC TGACCCCCAG CTTTAGCCCGTCGCGCATCG TCTTTCTACA GCACCTCGGC GGCGTTCTCG CCATTCCGAA CATTCGCGGCGGCAACGAGT ACGGCCAGTC GTGGCACGAC GCCGGGCGCC TTACGAAGAA GCAAAACTGTTTCACCGATT TCGTCTCCGC CGCCAAATAT CTCCACAGCA ACAAAATTGG CTCCCCTGCCACAACGGCCA TCATGGGCGG CTCCAACGGC GGCCTCCTCG TCGCCGCCTG CGCTAATCAAGCCCCTGACG AGTTCTCGTG CGTCGTGTGC CAAGTGGGCG TCCTTGACAT GTTCAAGTTTCACAAGTTCA CCATCGGCCA TGCTTGGATC TCCGACTACG GCAACCCGGA TGAGGAGGAGGACTTCAGGG TATTGGAGAA GTACAGCCCC ATCCACAATG TGCGCGCCGG CGTCAAGTACCCGGCCATCC TCGTGGTGAC CGGCGACCAT GATGATCGTG TGGTACCGCT GCATTCGCTCAAGTACGTCG CCACGCTGCA GCACGCGAAC CCGGAGCTGG GTGGTCCGTT CCTGGCGCGTGTGGAGGTGG CTGCCGGTCA CGGCTTCGGC AAGCCCACGA GCAAGATCAT CACCGAGACGTCCGACATGT ACGCCTTCAT GGCGAAGAAC ATTGGTGCAA CGTGGCATGA CTGA |
| Prolyl oligopeptidase, putative Q4Q080] | |
|---|---|
| Metabolite Information | proteolysis |
| Molecular Function | |
| Biochemical Pathway | |
| Regulatory Pathway | |
| KEGG Pathways | K01322 |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | prolyl endopeptidase [Homo sapiens] | 44 | 1e-168 | 590 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| ptrBa PROBABLE PROTEASE II PTRBA [FIRST PART] (OLIGOPEPTIDASE B) | Mycobacterium tuberculosis H37Rv | 25% | 0.00000003 | 54.7 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| PDOC00587 | Prolyl oligopeptidase family serine active site | 523-553; | PS00708 | |
| Acylation | N-myristoylation site | 216-221; 254-259; 375-380; 454-459; 490-495; 501-506; 537-542; 546-551; 547-552; 551-556; | PS00008 | |
| Glycosylation | N-glycosylation site | 95-98; | PS00001 | |
| Phosphorylation | cAMP- and cGMP-dependent protein kinase phosphorylation site | 452-455; | PS00004 | |
| Phosphorylation | Casein kinase II phosphorylation site | 21-24; 54-57; 104-107; 133-136; 142-145; 268-271; 269-272; 304-307; 320-323; 507-510; 694-697; | PS00006 | |
| Phosphorylation | Protein kinase C phosphorylation site | 104-106; 144-146; 304-306; 309-311; 390-392; 457-459; 515-517; 533-535; 639-641; 673-675; | PS00005 | |
| Phosphorylation | Tyrosine kinase phosphorylation site | 20-28; 146-152; | PS00007 | |
| Sulfation | Tyrosine sulfation site | 19-33; 21-35; 586-600; | PS00003 | |
| Prolyl oligopeptidase, putative [Q4Q080] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 1qfsA | |
| Percent Identity | 43% | |
| Target Region | 1-712 | |
| Template Region | 1-710 | |
| Domain Information | ||
|---|---|---|
| Domains | Start | End |
| Active Site Information | ||
|---|---|---|
| Residue | Active Site Number | Functional Part |
| SER | 548 | Sidechain |
| ASP | 631 | Sidechain |
| HIS | 667 | Sidechain |
| Co-Factor | |
|---|---|
| Metal | Description |
| Ligands | |||||
|---|---|---|---|---|---|
| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| N-BENZYLOXYCARBONYL-L-PROLYL-L-PROLINAL | 330.378 | C18 H22 N2 O4 | O=C(N1C(C=O)CCC1)C3N(C(=O)OCc2ccccc2)CCC3 | 1qfs | |
| Mutational Information | ||
|---|---|---|
| Residue | Feature | Description |
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| Modeled Protein | Template Structure |
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+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/289116/Q4Q080.pdb 2.0 697 = residues | | = | *| Ramachandran plot: 89.8% core 8.4% allow 0.8% gener 1.0% = disall | | = | *| All Ramachandrans: 21 labelled residues (out of 695) = | +| Chi1-chi2 plots: 5 labelled residues (out of 415) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | *| Residue properties: Max.deviation: 4.0 Bad contacts: = 6 | *| Bond len/angle: 9.3 Morris et al class: 1 = 1 2 | | = | | G-factors Dihedrals: -0.03 Covalent: -0.19 Overall: = -0.09 | | = | | M/c bond lengths: 99.2% within limits 0.8% highlighted = | *| M/c bond angles: 92.5% within limits 7.5% highlighted 1 off = graph | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |