| Coproporphyrinogen III oxidase [P84155] | |
|---|---|
| Systematic Name | LmjF.06.1270 [Leishmania major] |
| Gene Name | LMAJ006828 |
| Molecular Weight | 34370 Da |
| Protein Sequence Size | 301 |
| Function | |
| Charge | -6 |
| Isoelectric Point | 5.134 pH |
| Description | Coproporphyrinogen III oxidase (EC 1.3.3.3) (Coproporphyrinogenase) (Coprogen oxidase). |
| Subcellular Location | Cytoplasm[Predict] |
| E. C. Number | 1.3.3.3 |
| Sequence | >sp|P84155|HEM6_LEIMA Coproporphyrinogen III oxidase (EC 1.3.3.3) (Coproporphyrinogenase) (Coprogen oxidase) - Leishmania major. SLAVEAVKDFLLKLQDDICEALEAEDGQATFVEDKWTREGGGGGRTRVMVDGAVIEKGGV NFSHVYGKGLPMSSTERHPDIAGCNFEAMGVSLVIHPKNPHVPTSHANVRLFVAEREGKE PVWWFGGGFDLTPYYAVEEDCRDFHQVAQDLCKPFGADVYARFKGWCDEYFFIPYRNEAR GIGGLFFDDLNEWPFEKCFEFVQAVGKGYMDAYIPIVNRRKNTPYTEQQVEFQEFRRGRY AEFNLVIDRGTKFGLQSGGRTESILISLPPRARWGYNWQPEPGTPEARLTEYFLTKRQWV |
| DNA Sequence | >LmjF06.1270 |||coproporphyrinogen iii oxidase, putative|Leishmania major|chr 6|||Manual ATGTCGCTTG CAGTCGAAGC TGTAAAAGAC TTTCTCCTGA AGCTTCAGGA TGACATCTGTGAAGCTCTCG AGGCGGAGGA CGGACAGGCA ACATTTGTGG AAGATAAGTG GACACGCGAGGGCGGCGGTG GCGGCCGCAC GCGCGTCATG GTGGACGGTG CTGTGATCGA AAAGGGAGGCGTGAACTTTT CACACGTGTA CGGGAAAGGG CTGCCAATGT CTTCGACAGA GCGGCACCCGGACATAGCTG GTTGCAACTT CGAGGCGATG GGAGTCTCGC TTGTTATCCA TCCAAAGAACCCCCATGTCC CCACATCGCA CGCGAATGTG CGTCTGTTTG TTGCCGAGAG GGAAGGCAAGGAGCCGGTGT GGTGGTTCGG TGGCGGCTTC GACCTCACGC CGTACTATGC TGTGGAGGAAGACTGCCGCG ACTTCCACCA AGTTGCACAG GACCTCTGCA AGCCCTTTGG CGCTGACGTGTACGCGCGCT TCAAGGGGTG GTGTGACGAA TACTTCTTCA TCCCTTACCG AAACGAGGCCCGTGGTATCG GCGGCCTCTT TTTTGATGAC CTGAACGAGT GGCCGTTTGA GAAATGCTTCGAATTTGTGC AGGCAGTGGG CAAGGGCTAC ATGGATGCGT ACATCCCAAT TGTGAACCGGCGCAAGAACA CACCATACAC GGAACAGCAG GTGGAGTTCC AAGAGTTCCG CCGCGGACGGTACGCGGAGT TCAACCTGGT GATTGACCGC GGCACGAAGT TCGGCCTTCA GTCTGGCGGTCGCACCGAGT CCATCTTGAT TTCACTGCCG CCGCGCGCGC GCTGGGGCTA CAATTGGCAGCCAGAACCTG GTACGCCGGA GGCGCGGTTG ACGGAGTACT TTTTGACGAA GAGGCAGTGGGTGTAG |
| Coproporphyrinogen III oxidase P84155] | |
|---|---|
| Metabolite Information | |
| Molecular Function | coproporphyrinogen oxidase activity |
| Biochemical Pathway | porphyrin biosynthesis |
| Regulatory Pathway | |
| KEGG Pathways | K00228; lma00860 |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | coproporphyrinogen oxidase [Homo sapiens] | 44 | 1e-68 | 256 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| HI0418 transport protein | Haemophilus influenzae | 34% | 0.85 | 28.5 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| PDOC00595 | Formate--tetrahydrofolate ligase signatures | 62-65; | PS00722 | |
| Acylation | N-myristoylation site | 41-46; 43-48; 60-65; 70-75; 249-254; 253-258; 282-287; | PS00008 | |
| Glycosylation | N-glycosylation site | 62-65; | PS00001 | |
| Phosphorylation | cAMP- and cGMP-dependent protein kinase phosphorylation site | 219-222; | PS00004 | |
| Phosphorylation | Casein kinase II phosphorylation site | 31-34; 74-77; | PS00006 | |
| Phosphorylation | Protein kinase C phosphorylation site | 76-78; 294-296; | PS00005 | |
| Coproporphyrinogen III oxidase [P84155] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 2qt8B | |
| Percent Identity | 98% | |
| Target Region | 1-301 | |
| Template Region | 1-304 | |
| Domain Information | ||
|---|---|---|
| Domains | Start | End |
| Active Site Information | ||
|---|---|---|
| Residue | Active Site Number | Functional Part |
| Co-Factor | |
|---|---|
| Metal | Description |
| Ligands | |||||
|---|---|---|---|---|---|
| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| 71-50-1 | ACETATE ION | 59.044 | C2 H3 O2 | [O-]C(=O)C | 2qt8 |
| Mutational Information | ||
|---|---|---|
| Residue | Feature | Description |
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| Modeled Protein | Template Structure |
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+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/290016/P84155.pdb 2.0 301 = residues | | = | | Ramachandran plot: 95.2% core 4.8% allow 0.0% gener 0.0% = disall | | = | +| All Ramachandrans: 1 labelled residues (out of 299) = | +| Chi1-chi2 plots: 1 labelled residues (out of 182) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | | Residue properties: Max.deviation: 2.6 Bad contacts: = 2 | +| Bond len/angle: 4.5 Morris et al class: 1 = 1 2 | | = | | G-factors Dihedrals: 0.13 Covalent: -0.05 Overall: = 0.06 | | = | | M/c bond lengths: 99.4% within limits 0.6% highlighted = | | M/c bond angles: 95.3% within limits 4.7% highlighted = | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |