| Fructose-1,6-bisphosphatase, cytosolic [O97193] | |
|---|---|
| Systematic Name | LmjF.04.1160 [Leishmania major] |
| Gene Name | L2385.01 |
| Molecular Weight | 38826 Da |
| Protein Sequence Size | 351 |
| Function | |
| Charge | 7.5 |
| Isoelectric Point | 9.1 pH |
| Description | Fructose-1,6-bisphosphatase, cytosolic. |
| Subcellular Location | N.A.[Predict] |
| E. C. Number | N.A. |
| Sequence | >tr|O97193|O97193_LEIMA Fructose-1,6-bisphosphatase, cytosolic - Leishmania major DVRRTPTPTTLTQYIIKSQPPHSRGDFTLLMMAIQTSVKVIEKNIRRAGMKGMLGYIAGQ SANATGDHQAKLDVISNIAFKAYLLSSTSVCVLGSEEEEQMIIAESGRRGDYLIFFDPLD GSSNIDANVSVGSIWGVWRLPKDTTINSVEDANAVIRMLKGTDMVSAGYAVYGSATNLVL TSGHGVDGFTLDPNIGEFILTHPHISIPKKRSIYSVNEGNYGKWEPWFKEYIDYLKMNKT TRYSARYIGSMVGDIHRTLLYGGIFCYPKDANQVEGKLRLLYEAAPMAMIVEQAGGKAVG SNGRILEQSITRLHQRTPVYFGSRQEVDLCMAFRDRNVKTEALAPTSSKL |
| DNA Sequence | >LmjF04.1160 |||fructose-1,6-bisphosphatase, cytosolic, putative|Leishmania major|chr 4|||Manual ATGGACGTCA GACGCACCCC CACTCCCACT ACTCTCACCC AGTACATCAT CAAGAGCCAACCGCCGCACA GTCGTGGCGA CTTCACGCTC TTGATGATGG CGATTCAGAC GTCGGTGAAGGTGATTGAGA AGAACATCCG ACGTGCTGGC ATGAAGGGCA TGCTGGGCTA CATTGCTGGGCAGTCGGCGA ACGCGACGGG CGACCATCAG GCGAAGCTGG ATGTGATCTC GAACATAGCGTTCAAGGCGT ACCTGCTGAG CTCCACCAGC GTGTGCGTGC TCGGCAGCGA GGAGGAAGAGCAGATGATCA TCGCCGAGAG CGGCCGCCGT GGCGACTACC TCATCTTCTT CGACCCTCTTGACGGCAGCA GCAACATTGA TGCCAACGTC TCCGTAGGCT CTATCTGGGG CGTGTGGCGGCTGCCCAAGG ACACCACCAT AAACAGCGTC GAAGACGCCA ACGCCGTGAT CCGCATGCTTAAGGGAACAG ACATGGTTTC TGCCGGGTAC GCCGTGTACG GCAGTGCCAC GAACCTCGTGCTGACGAGCG GACACGGCGT GGACGGCTTC ACACTGGACC CCAACATTGG CGAGTTCATCCTGACACACC CGCACATCAG CATCCCGAAA AAGCGGAGCA TCTACAGCGT CAACGAGGGCAATTACGGCA AGTGGGAGCC GTGGTTTAAG GAGTATATCG ACTACCTCAA GATGAACAAGACAACCCGCT ACAGCGCGCG TTACATCGGC TCCATGGTCG GCGACATCCA CCGCACGCTCCTCTACGGCG GTATATTCTG TTACCCCAAG GACGCAAACC AGGTGGAGGG GAAGCTGCGCCTTCTGTACG AGGCCGCACC GATGGCGATG ATCGTGGAGC AGGCAGGCGG GAAGGCGGTGGGCAGCAACG GCCGTATCCT GGAGCAGTCC ATCACTCGCC TTCATCAGCG CACGCCGGTCTACTTCGGCA GCCGCCAGGA GGTGGACCTG TGCATGGCCT TCCGCGACCG CAACGTGAAGACGGAGGCAC TAGCACCGAC TTCCAGCAAG CTCTAA |
| Fructose-1,6-bisphosphatase, cytosolic O97193] | |
|---|---|
| Metabolite Information | |
| Molecular Function | |
| Biochemical Pathway | |
| Regulatory Pathway | |
| KEGG Pathways | K03841; lma00010; lma00030; lma00051; lma00710 |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | fructose-1,6-bisphosphatase 1 [Homo sapiens] | 47 | 8e-70 | 261 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| fbp fructose-16-bisphosphatase | Haemophilus influenzae | 43% | 4e-67 | 249 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| PDOC00016 | Cell attachment sequence | 25-27; 110-112 | PS00016 | |
| PDOC00595 | Formate--tetrahydrofolate ligase signatures | 64-67; 129-132; 239-242 | PS00722 | |
| PDOC00114 | Fructose-1-6-bisphosphatase active site | 277-289 | PS00124 | |
| PDOC00299 | Microbodies C-terminal targeting signal | 349-351 | PS00342 | |
| Acylation | N-myristoylation site | 60-65; 133-138; 174-179; 250-255; 263-268 | PS00008 | |
| Amidation | Amidation site | 107-110 | PS00009 | |
| Glycosylation | N-glycosylation site | 64-67; 129-132; 239-242 | PS00001 | |
| Phosphorylation | cAMP- and cGMP-dependent protein kinase phosphorylation site | 210-213 | PS00004 | |
| Phosphorylation | Casein kinase II phosphorylation site | 24-27; 96-99; 124-127; 149-152; 216-219; 324-327 | PS00006 | |
| Phosphorylation | Protein kinase C phosphorylation site | 38-40; 107-109; 241-243; 245-247; 348-350 | PS00005 | |
| Fructose-1,6-bisphosphatase, cytosolic [O97193] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 1spiD | |
| Percent Identity | 46% | |
| Target Region | 1-354 | |
| Template Region | 11-328 | |
| Domain Information | ||
|---|---|---|
| Domains | Start | End |
| Active Site Information | ||
|---|---|---|
| Residue | Active Site Number | Functional Part |
| ASP | 74 | Unknown |
| GLU | 198 | Unknown |
| Co-Factor | |
|---|---|
| Metal | Description |
| Ligands | |||||
|---|---|---|---|---|---|
| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| Mutational Information | ||
|---|---|---|
| Residue | Feature | Description |
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| Modeled Protein | Template Structure |
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+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/1324685/O97193.pdb 2.0 336 = residues | | = | *| Ramachandran plot: 79.0% core 16.2% allow 4.1% gener 0.7% = disall | | = | *| All Ramachandrans: 29 labelled residues (out of 334) = | +| Chi1-chi2 plots: 1 labelled residues (out of 197) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | *| Residue properties: Max.deviation: 4.0 Bad contacts: = 18 | *| Bond len/angle: 11.8 Morris et al class: 1 = 1 3 | | = | | G-factors Dihedrals: -0.18 Covalent: -0.35 Overall: = -0.24 | | = | | M/c bond lengths: 99.0% within limits 1.0% highlighted = | *| M/c bond angles: 91.7% within limits 8.3% highlighted 2 off = graph | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |