| Rad51 homolog [O61127] | |
|---|---|
| Systematic Name | LmjF.28.0550 [Leishmania major] |
| Gene Name | RAD51 |
| Molecular Weight | 41286 Da |
| Protein Sequence Size | 377 |
| Function | |
| Charge | -3.5 |
| Isoelectric Point | 5.7221 pH |
| Description | Rad51 homolog (RAD51 protein, putative). |
| Subcellular Location | N.A.[Predict] |
| E. C. Number | N.A. |
| Sequence | >tr|O61127|O61127_LEIMA Rad51 homolog (RAD51 protein, putative) - Leishmania major QTRSKAKGRRGRPSARPSEEVEVVESQPQEVLQNEEQEPQQQQQQQSTDMAEPNASGFRV IQILENYGVASSDIKKLMECGFYTVESAAYAPKKAILAVKGISENKAEKIMAECAKLVPM GFTSAVAYHEARKEIIMVTTGSREVDKLLGGGIETGSITELFGEFRTGKTQLCHTLCVTC QLPISQGGAEGMALYIDTEGTFRPERLVAVAERYKLDPEDVLANVACARAFNTDHQQQLL LQASAMMAENRFALIIVDSATALYRTDYSGRNELAARQMHLGKFLRSLHNLAEEYGVAVV VTNQVVANVDGSAQMFQADSKKPIGGHIMAHASTTRLSLRKGRGEQRIIKVYDSPCLAEA EAIFGIYDDGVGDARD |
| DNA Sequence | >LmjF28.0550 |RAD51||RAD51 protein, putative|Leishmania major|chr 28|||Manual ATGCAGACCC GTTCCAAGGC CAAAGGTCGC CGTGGTCGTC CGTCGGCGCG GCCCTCTGAAGAGGTTGAGG TTGTGGAGAG CCAGCCGCAG GAGGTCCTAC AGAACGAGGA GCAGGAGCCTCAGCAGCAGC AGCAGCAGCA GAGCACCGAC ATGGCTGAAC CGAACGCAAG TGGCTTTCGCGTTATCCAGA TCTTGGAGAA CTACGGCGTG GCCAGCTCAG ATATCAAGAA GCTCATGGAGTGCGGCTTTT ACACGGTGGA GTCGGCGGCC TACGCACCGA AGAAGGCCAT CCTGGCAGTGAAGGGGATCA GCGAGAACAA GGCCGAGAAA ATTATGGCGG AGTGCGCCAA GCTGGTGCCGATGGGGTTCA CTTCCGCGGT TGCCTACCAC GAGGCGCGCA AGGAGATCAT TATGGTCACTACGGGCAGCC GCGAGGTGGA CAAGCTACTC GGCGGCGGCA TCGAAACTGG GAGCATCACGGAGCTCTTCG GAGAGTTCCG TACGGGCAAG ACACAGCTCT GCCATACGCT GTGCGTGACGTGCCAGCTGC CCATCTCACA GGGTGGCGCG GAGGGCATGG CGCTCTATAT CGACACCGAAGGCACCTTCC GCCCGGAGCG CCTCGTTGCC GTTGCGGAGC GGTACAAGCT GGACCCGGAGGATGTGCTCG CTAACGTGGC GTGTGCGCGT GCCTTCAACA CGGATCACCA GCAGCAGCTGCTGCTGCAGG CGTCTGCCAT GATGGCCGAG AACCGCTTCG CGCTCATCAT TGTAGACTCTGCAACCGCTC TCTACCGCAC AGACTACAGC GGCCGCAACG AGCTCGCGGC GCGGCAGATGCACCTCGGCA AATTCTTGCG CTCGCTGCAC AACCTCGCCG AGGAGTACGG AGTGGCGGTGGTTGTGACAA ACCAGGTAGT GGCCAACGTG GACGGCTCCG CGCAGATGTT CCAGGCGGACTCCAAGAAGC CGATTGGAGG CCACATTATG GCCCACGCCT CGACGACGCG GCTTAGCCTGCGCAAGGGTC GTGGCGAGCA GCGCATCATA AAGGTGTACG ACTCTCCATG CCTGGCCGAGGCCGAGGCGA TCTTTGGCAT CTACGATGAT GGCGTTGGTG ATGCTCGGGA TTGA |
| Rad51 homolog O61127] | |
|---|---|
| Metabolite Information | |
| Molecular Function | ATP binding; DNA binding; DNA-dependent ATPase activity; damaged DNA binding; nucleoside-triphosphatase activity; nucleotide binding |
| Biochemical Pathway | DNA metabolism; DNA repair |
| Regulatory Pathway | |
| KEGG Pathways | K04482 |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | RAD51 homolog protein isoform 1 [Homo sapiens] | 67 | 1e-121 | 430 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| recA RecA/RadA recombinase | Staphylococcus aureus | 26% | 0.0002 | 41.2 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| PDOC00017 | ATP/GTP-binding site motif A (P-loop) | 164-171 | PS00017 | |
| PDOC00595 | Formate--tetrahydrofolate ligase signatures | 55-58 | PS00722 | |
| PDOC00131 | recA family signature and profiles | 135-310 | PS50162 | |
| PDOC00131 | recA family signature and profiles | 314-377 | PS50163 | |
| PDOC50099 | Sequence regions enriched in a particular amino acids | 28-47 | PS50322 | |
| Acylation | N-myristoylation site | 69-74; 102-107; 152-157; 153-158; 188-193; 371-376 | PS00008 | |
| Amidation | Amidation site | 11-08-2022 00:00:00 | PS00009 | |
| Glycosylation | N-glycosylation site | 55-58 | PS00001 | |
| Phosphorylation | Casein kinase II phosphorylation site | 158-161 | PS00006 | |
| Phosphorylation | Protein kinase C phosphorylation site | 15-17; 168-170; 202-204; 270-272; 321-323; 335-337; 339-341 | PS00005 | |
| Phosphorylation | Tyrosine kinase phosphorylation site | 76-84 | PS00007 | |
| Sulfation | Tyrosine sulfation site | 189-203 | PS00003 | |
| Rad51 homolog [O61127] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 1szpF | |
| Percent Identity | 58% | |
| Target Region | 1-377 | |
| Template Region | 80-294 | |
| Domain Information | ||
|---|---|---|
| Domains | Start | End |
| Active Site Information | ||
|---|---|---|
| Residue | Active Site Number | Functional Part |
| Co-Factor | |
|---|---|
| Metal | Description |
| Ligands | |||||
|---|---|---|---|---|---|
| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| 14808-79-8 | SULFATE ION | 96.063 | O4 S   | [O-]S([O-])(=O)=O | 1szp |
| Mutational Information | ||
|---|---|---|
| Residue | Feature | Description |
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| Modeled Protein | Template Structure |
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+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/2390800/O61127.pdb 2.0 377 = residues | | = | *| Ramachandran plot: 91.6% core 7.2% allow 0.6% gener 0.6% = disall | | = | *| All Ramachandrans: 14 labelled residues (out of 375) = | +| Chi1-chi2 plots: 4 labelled residues (out of 216) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | *| Residue properties: Max.deviation: 4.0 Bad contacts: = 3 | *| Bond len/angle: 9.2 Morris et al class: 1 = 1 3 | +| 1 cis-peptides = | | G-factors Dihedrals: -0.06 Covalent: -0.42 Overall: = -0.19 | | = | | M/c bond lengths: 98.0% within limits 2.0% highlighted = | *| M/c bond angles: 89.1% within limits 10.9% highlighted 2 off = graph | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |