PI-510: Introduction to Pharmacoinformatics		(1 credit)
1.	Introduction of bioinformatics: Different sub domains of bioinformatics, Applications; Amino acid and nucleic acid structure; Properties.
2.	Protein folding: Concept, Theoretical and experimental techniques to identify the molecular structure; Principles of protein structure; Structural bioinformatics in drug discovery, Metric system.
3.	Structural genomics: Approaches, Structural genomics effort, Protein structural initiative, structural genomics consortium, Impact of structural genomics.
4.	Introduction to chemoinformatics: Chemoinformatics and drug discovery, Simulation methods and their importance, Representation of molecules, Visualization and generation of 2D and 3D molecular structures; Molecular modeling, Data analysis, Chemical information.
5.	Databases and its importance: 2D and 3D databases, Structural and chemical databases, Implications.
6.	Energy of molecules: Bioactive conformation of the molecules, Crystallography, energy minimized and bioactive conformation, Conformational search approaches, Force field, Potential energy surface, Different conformations, examples.
7.	Ligand based drug design: Overview, Similarity methods, Superimposition methods, Pharmacophore, QSAR methods.
8.	Structure based methods: Overview, Introduction to molecular docking methods, scoring function, synergy between ligand and structure-based methods.
9.	ADME/T predictive methods: Overview of methods, in silico approaches to ADME/T models, pharmaceutical issues; software tools in ADME/T prediction, limitations of in silico approaches.
10.	Applications: Application of bioinformatics, chemoinformatics, ADME/T in drug discovery and development.