Registration No.:	PI/2011/XIX/310/P
Name:	Rameshwar Prajapati
Connect at:	Linkedin
Ph.D. Thesis Title:
Molecular insights on substrates and inhibitors binding of human pglycoprotein using multi-targeted molecular dynamics and in vitro inhibition studies on P-glycoprotein
Research: 8
Thanki K, Prajapati R, Sangamwar AT, Jain S. Long chain fatty acid conjugation remarkably decreases the aggregation induced toxicity of Amphotericin B. International Journal of Pharmaceutics 2018, 544: 1-13.
Singh U, Gangwal RP, Dhoke GV, Prajapati R, Damre M and Sangamwar AT. 3D-QSAR and Molecular Docking Analysis of (4-Piperidinyl)-Piperazines as Acetyl-CoA Carboxylases Inhibitors. Arabian Journal of Chemistry 2017, 10: S617-S626.
Aggarwal G, Prajapati R, Tripathy RK, Bajaj P, Iyengar AR, Sangamwar AT, Pande AH. Toward Understanding the Catalytic Mechanism of Human Paraoxonase 1: Site-Specific Mutagenesis at Position 192. PLoS One 2016, 11: e0147999.
Tripathi SP, Prajapati R, Verma N and Sangamwar AT. Predicting substrate selectivity between UGT1A9 and UGT1A10 using molecular modelling and molecular dynamics approach. Molecular Simulation 2016, 42: 270-288.
Khandelwal K, Gangwal RP, Singh U, Prajapati R, Damre MV, Sangamwar AT. Computational insights into the active site of human breast cancer resistance protein (BCRP/ABCG2): a similarity search approach. Medicinal Chemistry Research 2014, 23: 4657-4668.
Prajapati R, Sangamwar AT. Translocation mechanism of P-glycoprotein and conformational changes occurring at drug-binding site: Insights from multi-targeted molecular dynamics. Biochimica et Biophysica Acta (BBA) - Biomembranes 2014, 1838: 2882-2898.
Prajapati R, Singh U, Patil A, Khomane KS, Bagul P, Bansal AK and Sangamwar AT. In silico model for P-glycoprotein substrate prediction: insights from molecular dynamics and in vitro studies. Journal of Computer-Aided Molecular Design 2013, 27: 347-363.
Singh U, Gangwal RP, Prajapati R, Dhoke GV and Sangamwar AT. 3D QSAR pharmacophore based virtual screening and molecular docking studies to identify novel matrix metalloproteinase 12 (MMP-12) inhibitors. Molecular Simulation 2013, 39: 385-396.
Review: 1
Jain S, Rathod V, Prajapati R, Nandekar PP, Sangamwar AT. Pregnane X Receptor and P-glycoprotein: a connexion for Alzheimer's disease management. Molecular Diversity 2014, 18: 895-909.