Registration No.: PI/2011/XIX/309/P
Name: Rajender Kumar
Ph.D. Thesis Title: Identification and design of novel inhibitors against aspartate-semialdehyde dehydrogenase for Mycobacterium tuberculosis using computational approaches
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Research: 15
Kumar A, Kumar R, Boradia VM, Malhotra H, Kumar A, Shankar G, Jhadav A, Jhansi E, Garg P, Karthikeyan S, Raje M, Raje CI. Stoichiometry of ligand binding and role of C-terminal lysines in Mycobacterium tuberculosis and human GAPDH multifunctionality. FEBS Journal 2024, .
Dhumal TT, Kumar R, Paul A, Roy PK, Garg P, Singh S. Molecular explorations of the Leishmania donovani 6-Phosphogluconolactonase enzyme, a key player in the Pentose Phosphate Pathway. Biochimie 2022, 202: 212-225.
Malhotra H, Patidar A, Boradia VM, Kumar R, Nimbalkar RD, Kumar A, Gani Z, Kaur R, Garg P, Raje M, Raje CI. Mycobacterium tuberculosis Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) functions as a receptor for human lactoferrin. Frontiers in Cellular and Infection Microbiology 2017, DOI: 10.3389/fcimb.2017.00245.
Kumar R, Garg P and Bharatam PV. Pharmacoinformatics Analysis to Identify Inhibitors of Mtb-ASADH. Journal of Biomolecular Structure and Dynamics 2016, 34: 1-14.
Kumar R, Sethi R, Shah P, Roy I, Singh IP, Bharatam PV, Tewari R and Garg P. Biological Evaluation of Small Molecule Inhibitors of Mtb-ASADH Enzyme. Letters in Drug Design & Discovery 2016, 13: 587-590.
Kumar R, Garg P and Bharatam PV. Shape-based virtual screening, docking and molecular dynamics simulations to identify Mtb-ASADH inhibitors. Journal of Biomolecular Structure and Dynamics 2015, 33: 1082-1093.
Kumar R, Sharma M, Shaikh N, Garg P. A comparative study of integrase binding domain of homologous HRP2 and LEDGF/p75 protein: From sequence to structural characterization. Molecular Simulation 2015, 41: 683-690.
Sharma PK, Kumar R, Garg P, Kaur J. Insights into controlling role of substitution mutation, E315G on thermostability of a lipase cloned from metagenome of hot spring soil. 3 Biotech 2014, 4: 189-196.
Kumar R, Garg P. Molecular Modeling and Active Site Binding Mode Characterization of Aspartate β-Semialdehyde Dehydrogenase Family. Molecular Informatics 2013, 32: 377-383.
Toor JS, Sharma A, Kumar R, Garg P and Arora SK. Prediction of High Level of Multiple Drug Resistance Mutations in HIV-1 Subtype C Reverse Transcriptase Gene among First Line Antiretroviral-Experienced Virological Failure Patients from North India Using Genotypic and Docking Analysis. Journal of AIDS and Clinical Research 2013, S5: doi: 10.4172/2155-6113.S5-005.
Bodiwala HS, Sabde S, Gupta P, Mukherjee R, Kumar R, Garg P, Bhutani KK, Mitra D and Singh IP. Design and Synthesis of Caffeoyl-Anilides as Portmanteau Inhibitors of HIV-1 Integrase and CCR5. Bioorganic & Medicinal Chemistry 2011, 19: 1256-1263.
Toor JS, Sharma A, Kumar R, Gupta P, Garg P and Arora SK. Prediction of drug-resistance in HIV-1 Subtype C based on protease sequences from ART naive and first-line treatment failures in North India using genotypic and docking analysis. Antiviral Research 2011, 92: 213-218.
Gupta P, Kumar R, Garg P and Singh IP. Active site binding modes of dimeric phloroglucinols for HIV-1 reverse transcriptase, protease and integrase. Bioorganic & Medicinal Chemistry Letters 2010, 20: 4427-4431.
Kumar R and Garg P. Active site binding interactions of β-carboline derivative for HIV reverse transcriptase, protease and integrase. International Journal of Drug Discovery 2010, 2: 51-55.
Singh IP, Jain SK, Kaur A, Singh S, Kumar R, Garg P, Sharma SS and Arora SK. Synthesis and Antileishmanial activity of Piperoyl-Amino Acid Conjugates. European Journal of Medicinal Chemistry 2010, 45: 3439-3445.
Review: 1
Kumar R, R R, Diwakar V, Khan N, Meghwanshi GK, Garg P. Structural–functional analysis of drug targets for aspartate semialdehyde dehydrogenase. Drug Discovery Today 2024, 103908.
Books/Book Chapters: 0