Registration No.:	PI/2010/XVIII/277/P
Name:	Nandekar Prajwal Prabhakarrao
Connect at:	Linkedin
Ph.D. Thesis Title:
Design and Development of Anticancer Compounds Targetting Cytochrome P450 1A1
Research: 13
Kesharwani SS, Nandekar PP, Pragyan P, Rathod V, Sangamwar AT. Characterization of differences in substrate specificity among CYP1A1, CYP1A2 and CYP1B1: an integrated approach employing molecular docking and molecular dynamics simulations. Journal of Molecular Recognition 2016, 29: 370-90.
Meena CL, Thakur A, Nandekar PP, Sharma SS, Sangamwar AT, Jain R. Synthesis and biology of ring-modified l-Histidine containing thyrotropin-releasing hormone (TRH) analogues. European Journal of Medicinal Chemistry 2016, 111: 72-83.
Nandekar PP, Khomane K, Chaudhary V, Rathod VP, Borkar RM, Bhandi MM, Srinivas R, Sangamwar AT, Guchhait SK, Bansal AK. Identification of leads for antiproliferative activity on MDA-MB-435 human breast cancer cells through pharmacophore and CYP1A1-mediated metabolism. European Journal of Medicinal Chemistry 2016, 115: 82-93.
Borkar RM, Bhandi MM, Dubey AP, Nandekar PP, Sangamwar AT, Banerjee SK, Srinivas R. Plasma protein binding, pharmacokinetics, tissue distribution and CYP450 biotransformation studies of fidarestat by ultra high performance liquid chromatography-high resolution mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis 2015, 102: 386-399.
Meena CL, Ingole S, Rajpoot S, Thakur A, Nandekar PP, Sangamwar AT, Sharma SS, Jain R. Discovery of a low affinity thyrotropin-releasing hormone (TRH)-like peptide that exhibits potent inhibition of scopolamine-induced memory impairment in mice. RSC Advances 2015, 5: 56872-56884.
Bagul P, Khomane KS, Kesharwani SS, Pragyan P, Nandekar PP, Meena CL, Bansal AK, Jain R, Tikoo K, Sangamwar AT. Intestinal transport of TRH analogs through PepT1: the role of in silico and in vitro modeling. Journal of Molecular Recognition 2014, 27: 609-617.
Kalariya PD, Raju B, Borkar RM, Namdev D, Gananadhamu S, Nandekar PP, Sangamwar AT, Srinivas R. Characterization of forced degradation products of ketorolac tromethamine using LC/ESI/Q/TOF/MS/MS and in silico toxicity prediction. Journal of Mass Spectrometry 2014, 49: 380-391.
Kesharwani SS, Nandekar PP, Pragyan P, Sangamwar AT. Comparative proteomics among cytochrome p450 family 1 for differential substrate specificity. The Protein Journal 2014, 33: 536-548.
Pragyan P, Kesharwani SS, Nandekar PP, Rathod V, Sangamwar AT. Predicting drug metabolism by CYP1A1, CYP1A2, and CYP1B1: insights from MetaSite, molecular docking and quantum chemical calculations. Molecular Diversity 2014, 18: 865-878.
Tumbi KM, Nandekar PP, Shaikh N, Kesharwani SS, Sangamwar AT. Molecular dynamics simulation studies for DNA sequence recognition by reactive metabolites of anticancer compounds. Journal of Molecular Recognition 2014, 27: 138-150.
Yadav IS, Nandekar PP, Srivastavaa S, Sangamwar A, Chaudhury A, Agarwal SM. Ensemble docking and molecular dynamics identify knoevenagel curcumin derivatives with potent anti-EGFR activity Corrigendum at DOI: 10.1016/j.gene.2014.02.035. Gene 2014, 539: 82-90.
Chobe SS, Dawane BS, Tumbi KM, Nandekar PP and Sangamwar AT. An ecofriendly synthesis and DNA binding interaction study of some pyrazolo [1,5-a]pyrimidines derivatives. Bioorganic & Medicinal Chemistry Letters 2013, 22: 7566-7572.
Khomane KS, Nandekar PP, Wahlang B, Bagul P, Shaikh N, Pawar YB, Meena CL, Sangamwar AT, Jain R, Tikoo K and Bansal AK. Molecular mechanistic insights into the PepT1-mediated intestinal transport of a novel antiepileptic, NP-647. Molecular Pharmaceutics 2012, 9: 2458-2468.
Review: 3
Jain S, Rathod V, Prajapati R, Nandekar PP, Sangamwar AT. Pregnane X Receptor and P-glycoprotein: a connexion for Alzheimer's disease management. Molecular Diversity 2014, 18: 895-909.
Rathod V, Jain S, Nandekar PP and Sangamwar AT. Human pregnane X receptor: A novel target for anticancer drug development. Drug Discovery Today 2013, 19: 63-70.
Nandekar PP and Sangamwar AT. Cytochrome P450 1A1-mediated anticancer drug discovery: in silico findings. Expert Opinion on Drug Discovery 2012, 7: 771-789.