InAADR

Protein Information

Protein Name: phospholipases C (Q9NQ66)
Gene Name: PLCB1
Description: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 1 (EC 3 1 4 11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-1) (PLC-beta-1) (PLC-I) (PLC-154)
PDB ID:
Protein Family:
Protein Category: Enzyme

This panel provides drug-protein interaction and their ADRs along with references

Interacting Drugs Toxicity Mechanism Reference
Amikacin Aminoglycoside Toxicity Amikacin inhibited both phospholipase A and phospholipase C@which is possible mechanism of aminoglycoside toxicity [ ADR Type 1 ] Inhibition of kidney lysosomal phospholipases A and C by aminoglycoside antibiotics: possible mechanism of aminoglycoside toxicity
Aminoglycoside Nephrotoxicity Aminoglycosides are able to inhibit phosphatidylinositol phospholipase C activity@which may be related to the nephrotoxicity of aminoglycosides. [ ADR Type 1 ] Aminoglycoside inhibition of a renal phosphatidylinositol phospholipase
Dibekacin Aminoglycoside Toxicity Dibekacin inhibited both phospholipase A and phospholipase C@which is a possible mechanism of aminoglycoside toxicity. [ ADR Type 1 ] Inhibition of kidney lysosomal phospholipases A and C by aminoglycoside antibiotics: possible mechanism of aminoglycoside toxicity
Gentamicin Aminoglycoside Toxicity Gentamicin inhibited both phospholipase A and phospholipase C@which is a possible mechanism of aminoglycoside toxicity. [ ADR Type 1 ] Inhibition of kidney lysosomal phospholipases A and C by aminoglycoside antibiotics: possible mechanism of aminoglycoside toxicity
Tobramycin Aminoglycoside Toxicity Tobramycin inhibited both phospholipase A and phospholipase C@which is a possible mechanism of aminoglycoside toxicity [ ADR Type 1 ] Inhibition of kidney lysosomal phospholipases A and C by aminoglycoside antibiotics: possible mechanism of aminoglycoside toxicity

This panel provides information on drug category

Toxicity Source

InAADR: Drug-Protein-ADRs database