| Protein Name: | UDP-glucuronosyltransferase 1-9 (O60656) |
|---|---|
| Gene Name: | UGT1A9 |
| Description: | UDP-glucuronosyltransferase 1-9 precursor (EC 24117) (UDP- glucuronosyltransferase 1A9) (UDPGT) (UGT1 9) (UGT1-9) (UGT19) (UGT- 1I) (UGT1I) |
| PDB ID: | |
| Protein Family: | |
| Protein Category: | Enzyme |
This panel provides drug-protein interaction and their ADRs along with references
| Interacting Drugs | Toxicity | Mechanism | Reference |
|---|---|---|---|
| Acetaminophen | Toxicity In Human Hepatocytes | The inhibition of APAP glucuronidation by phenobarbital leads to an increase in APAP-mediated toxicity in human hepatocytes;The toxicity to hepatocytes was further increased by coadministering APAP with phenytoin and phenobarbital;This synergistic increase in toxicity is postulated to be due to inhibition of UGTs. [ ADR Type 4 ] | Kinetics of acetaminophen glucuronidation by UDP-glucuronosyltransferases 1A1, 1A6, 1A9 and 2B15 Potential implications in acetaminophen-induced hepatotoxicity |
This panel provides information on drug category
| Toxicity | Source |
|---|