| Protein Name: | UDP-glucuronosyltransferase 1-6 (P19224) |
|---|---|
| Gene Name: | UGT1A6 |
| Description: | UDP-glucuronosyltransferase 1-6 precursor (EC 2 4 1 17) (UDP- glucuronosyltransferase 1A6) (UDPGT) (UGT1*6) (UGT1-06) (UGT1 6) (UGT- 1F) (UGT1F) (Phenol-metabolizing UDP-glucuronosyltransferase) |
| PDB ID: | |
| Protein Family: | |
| Protein Category: | Enzyme |
This panel provides drug-protein interaction and their ADRs along with references
| Interacting Drugs | Toxicity | Mechanism | Reference |
|---|---|---|---|
| Acetaminophen | Apap-Mediated Toxicity In Human Hepatocytes | The inhibition of APAP glucuronidation by phenobarbital leads to an increase in APAP-mediated toxicity in human hepatocytes;The toxicity to hepatocytes was further increased by coadministering APAP with phenytoin and phenobarbital;This synergistic increase in toxicity is postulated to be due to inhibition of UGTs [ ADR Type 4 ] | Kinetics of acetaminophen glucuronidation by UDP-glucuronosyltransferases 1A1, 1A6, 1A9 and 2B15 Potential implications in acetaminophen-induced hepatotoxicity |
| Acetaminophen | Toxicity In Human Hepatocytes | The inhibition of APAP glucuronidation by phenobarbital leads to an increase in APAP-mediated toxicity in human hepatocytes;The toxicity to hepatocytes was further increased by coadministering APAP with phenytoin and phenobarbital;This synergistic increase in toxicity is postulated to be due to inhibition of UGTs [ ADR Type 4 ] | Kinetics of acetaminophen glucuronidation by UDP-glucuronosyltransferases 1A1, 1A6, 1A9 and 2B15 Potential implications in acetaminophen-induced hepatotoxicity |
This panel provides information on drug category
| Toxicity | Source |
|---|