| Protein Name: | Transcription factor E2F1 (Q01094) |
|---|---|
| Gene Name: | E2F1 |
| Description: | Transcription factor E2F1 (E2F-1) (Retinoblastoma-binding protein 3) (RBBP-3) (PRB-binding protein E2F-1) (PBR3) (Retinoblastoma-associated protein 1) (RBAP-1) |
| PDB ID: | 1H24 |
| Protein Family: | |
| Protein Category: | Transcription Factor |
This panel provides drug-protein interaction and their ADRs along with references
| Interacting Drugs | Toxicity | Mechanism | Reference |
|---|---|---|---|
| Estradiol | Cytotoxicity | Estradiol promotes a rapid reduction in levels of the E2F-1 and Myc proteins@which may influence the nature of the antiproliferative and Cytotoxicity of the breast tumor cell. [ ADR Type 1 ] | Rb dephosphorylation and suppression of E2F activity in human breast tumor cells exposed to a pharmacological concentration of estradiol |
This panel provides information on drug category
| Toxicity | Source |
|---|