This panel provides drug-protein interaction and their ADRs along with references
| Interacting Drugs |
Toxicity |
Mechanism |
Reference |
|---|
| Cisplatin | Emesis | Superoxide dismutase change significantly in cisplatin-induced emesis in Suncus murinus. [ ADR Type 2 ] | Involvement of free radicals in cisplatin-induced emesis in Suncus murinus
|
| Cisplatin | Ototoxicity | Cisplatin ototoxicity is related to depletion of glutathione and superoxide dismutase in the cochlea [ ADR Type 2 ] | Application of antioxidants and other agents to prevent cisplatin ototoxicity
|
| Cyclophosphamide | Lung Toxicity | Significant reductions (P less than 0 005) in G6PD, GSH-R, and GSH-P activities occurred on days 1-5,indicating that Cyclophosphamide causes lung toxicity [ ADR Type 2 ] | Cyclophosphamide-induced depression of the antioxidant defense mechanisms of the lung
|
| Haloperidol | Orofacial Dyskinesia | Coadministration of Ws extract significantly reduced the lipid peroxidation and significantly reversed the decrease in forebrain SOD and catalase levels, which strongly suggests that oxidative stress plays a significant role in HP-induced orofacial dyskinesia [ ADR Type 1 ] | Effect of Withania somnifera root extract on haloperidol-induced orofacial dyskinesia: possible mechanisms of action
|
| Peplomycin (PLM) | Pulmonary Fibrosis | In vitro, peplomycin(PLM) up-regulated the release of interleukin-1 beta, interleukin-6, tumor necrosis factor alpha, and granulocyte-macrophage colony-stimulating factor both from human cells and from RAM and pulmonary fibroblasts,which are the causative factors of PLM-induced pulmonary fibrosis. [ ADR Type 2 ] | Contrasting influence of peplomycin and azelastine hydrochloride (Azeptin) on reactive oxygen generation in polymorphonuclear leukocytes, cytokine generation in lymphocytes, and collagen synthesis in fibroblasts
|
This panel provides information on drug category