InAADR

Protein Information

Protein Name: Sodium-dependent serotonin transporter (P31645)
Gene Name: SLC6A4
Description:
PDB ID: 5I6X
Protein Family: PF03491, PS00610
Protein Category: Transporters

This panel provides drug-protein interaction and their ADRs along with references

Interacting Drugs Toxicity Mechanism Reference
Clomipramine Antidepressant Response 5-Hydroxytryptamine neurotransmission@antidepressant response. [ ADR Type 1 ] Serotonin transporter gene polymorphism and antidepressant response
Fluoxetine Antidepressant Response 5-Hydroxytryptamine neurotransmission@antidepressant response. [ ADR Type 1 ] Serotonin transporter gene polymorphism and antidepressant response
Haloperidol Tardive Dyskinesia Haloperidol tetrahydropyridine (HPTP) inhibited the presynaptic uptake of dopamine and serotonin@ with greater affinity for the serotonin transporter@which is concerning a possible role of HP metabolites in the development of tardive dyskinesia [ ADR Type 1 ] Effects of haloperidol metabolites on neurotransmitter uptake and release: possible role in neurotoxicity and tardive dyskinesia
Paroxetine Antidepressant Response 5-Hydroxytryptamine neurotransmission@antidepressant response. [ ADR Type 1 ] Serotonin transporter gene polymorphism and antidepressant response
Terfenadine Hyperhidrosis Not Available Large-scale prediction and testing of drug activity on side-effect targets

This panel provides information on drug category

Toxicity Source
Anticholinergic Syndrome Large-scale prediction and testing of drug activity on side-effect targets
Anxiety Vulnerability to mild predator stress in serotonin transporter knockout mice
Blood Glucose Abnormal Large-scale prediction and testing of drug activity on side-effect targets
Conduction Disorder Large-scale prediction and testing of drug activity on side-effect targets
Cycloplegia Large-scale prediction and testing of drug activity on side-effect targets
Dependence Large-scale prediction and testing of drug activity on side-effect targets
Dry Mouth Large-scale prediction and testing of drug activity on side-effect targets
Erectile Dysfunction Large-scale prediction and testing of drug activity on side-effect targets
Extrapyramidal Disorder Large-scale prediction and testing of drug activity on side-effect targets
Galactorrhoea Large-scale prediction and testing of drug activity on side-effect targets
Hyperhidrosis Large-scale prediction and testing of drug activity on side-effect targets
Hypomania Large-scale prediction and testing of drug activity on side-effect targets
Insomnia Large-scale prediction and testing of drug activity on side-effect targets
Irritable Bowel Syndrome Serotonin transporter gene polymorphism and irritable bowel syndrome
Libido Disorder Large-scale prediction and testing of drug activity on side-effect targets
Mania Large-scale prediction and testing of drug activity on side-effect targets
Nervousness Large-scale prediction and testing of drug activity on side-effect targets
Orthostatic Hypotension Large-scale prediction and testing of drug activity on side-effect targets
Palpitations Large-scale prediction and testing of drug activity on side-effect targets
Psychotic Disorder Large-scale prediction and testing of drug activity on side-effect targets
Schizophrenia Large-scale prediction and testing of drug activity on side-effect targets
Sexual Dysfunction Large-scale prediction and testing of drug activity on side-effect targets
Sleep Disorder Large-scale prediction and testing of drug activity on side-effect targets
Tachycardia Large-scale prediction and testing of drug activity on side-effect targets
Tremor Large-scale prediction and testing of drug activity on side-effect targets
Urinary Retention Large-scale prediction and testing of drug activity on side-effect targets
Weight Decreased Large-scale prediction and testing of drug activity on side-effect targets

InAADR: Drug-Protein-ADRs database