| Protein Name: | Sodium/potassium-transporting ATPase (P05023) |
|---|---|
| Gene Name: | ATP1A1 |
| Description: | Sodium/potassium-transporting ATPase alpha-1 chain precursor (EC 3 6 3 9) (Sodium pump 1) (Na+/K+ ATPase 1) |
| PDB ID: | |
| Protein Family: | |
| Protein Category: | Enzyme | Transporters |
This panel provides drug-protein interaction and their ADRs along with references
| Interacting Drugs | Toxicity | Mechanism | Reference |
|---|---|---|---|
| Digoxin | Mitochondrial Defects | Membrane Na+-K+ ATPase inhibition due to elevated diGOxin@which induced alteration in intracellular calcium/magnesium ratios and low ubiquinone levels can lead to a mitochondrial dysfunction [ ADR Type 1 ] | Hypothalamic digoxin mediated model for oncogenesis |
| Gentamicin | Necrosis | Treatment with Gentamicin will cause a selective inhibition of Na@K(+)-ATPase in the proximal tubule cells@where it will produce necrosis. [ ADR Type 2 ] | Gentamicin inhibition of Na+,K(+)-ATPase in rat kidney cells |
| Reserpine | Ulcer | Before the appearance of reserpine ulcer@ significant changes in the feedback mechanism system@ i.e. between the ATP--membrane ATPase--ADP and the ATP--adenylate cyclase--cAMP energy systems@ can be observed in the rat gastric fundal mucosa. [ ADR Type 2 ] | Cellular energy systems and reserpine ulcer in rats |
This panel provides information on drug category
| Toxicity | Source |
|---|