| Protein Name: | Signal transducer and activator of transcription 3 (P40763) |
|---|---|
| Gene Name: | STAT3 |
| Description: | Signal transducer and activator of transcription 3 (Acute-phase response factor) |
| PDB ID: | |
| Protein Family: | |
| Protein Category: | Transcription Factor |
This panel provides drug-protein interaction and their ADRs along with references
| Interacting Drugs | Toxicity | Mechanism | Reference |
|---|---|---|---|
| Dehydrated Alcohol | Alcohol Intoxication | Time-dependent increases in phospho-extracellular signal-regulated kinase (ERK) 1/2 were found to occur simultaneously with increases in serine 727 phospho-Stat3 [ ADR Type 2 ] | Alcohol-induced c-Fos expression in the Edinger-Westphal nucleus: pharmacological and signal transduction mechanisms |
| Dexamethasone | Apoptosis | Stimulation with either IFN-alpha or IL-6 resulted in STAT3 phosphorylation@which may induce apoptosis when treating with dexamethasone [ ADR Type 5 ] | IFN-alpha is a survival factor for human myeloma cells and reduces dexamethasone-induced apoptosis |
| Dexamethasone | Oxidative Injury Such As Endotoxins And Heme | STAT3-specific probe inhibited nuclear binding protein to the putative HO-1-STAT3 sequence@suggestting that IL-6 induction of human HO-1 is mediated via the JAK-STAT pathway@which leads to promote oxidative injury such as endotoxins and heme. [ ADR Type 5 ] | Negative regulation of human heme oxygenase in microvessel endothelial cells by dexamethasone |
This panel provides information on drug category
| Toxicity | Source |
|---|