| Protein Name: | C-jun-amino-terminal kinase-interacting protein (Q9UQF2) |
|---|---|
| Gene Name: | MAPK8IP1 |
| Description: | C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain 1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1) |
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This panel provides drug-protein interaction and their ADRs along with references
| Interacting Drugs | Toxicity | Mechanism | Reference |
|---|---|---|---|
| c-JUN | Apoptosis | Induction of apoptotic cell death and DNA damage by treatment of U937 cells with etoposide (100 microM) was associated with phosphorylation and activation of the c-Jun NH(2)-terminal kinase (JNK1) SAPK enzymes p46 and p54-JNK2 and transient increases in expression of the transcription factor c-Jun@ a primary JNK substrate. [ ADR Type 2 ] | Evidence that the apoptotic actions of etoposide are independent of c-Jun/activating protein-1-mediated transregulation |
| Dexamethasone | Apoptosis Of Multiple Myeloma Cells | Associated with activation of SAPK/JNK and p38 kinase@which leads to apoptosis of multiple myeloma cells in a JNK/SAP kinase independent mechanism. [ ADR Type 2 ] | Dexamethasone induces apoptosis of multiple myeloma cells in a JNK/SAP kinase independent mechanism |
This panel provides information on drug category
| Toxicity | Source |
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