| Protein Name: | Opioid growth factor receptor (Q9NZT2) |
|---|---|
| Gene Name: | OGFR |
| Description: | Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein) |
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This panel provides drug-protein interaction and their ADRs along with references
| Interacting Drugs | Toxicity | Mechanism | Reference |
|---|---|---|---|
| Dehydrated Alcohol | Alcohol Intoxication | Positive modulators for the GABA(A) receptor (20 mg/kg 3alpha-hydroxy-5alpha-pregnan-20-one and 10-30 mg/kg chlordiazepoxide) and opioid receptor (10 mg/kg morphine) produced significant elevations on Edinger-Westphal c-Fos expression@showing that the Edinger-Westphal nucleus is preferentially sensitive to alcohol intoxication [ ADR Type 1 ] | Alcohol-induced c-Fos expression in the Edinger-Westphal nucleus: pharmacological and signal transduction mechanisms |
| Fentanyl | Pain Enhancement | PKCgamma as a key element that links opioid receptor activation with the recruitment of opposite systems to opioid analgesia involved in a physiological compensatory pain enhancement [ ADR Type 2 ] | Prevention of fentanyl-induced delayed pronociceptive effects in mice lacking the protein kinase Cgamma gene |
| Levodopa | Parkinsonism | Non-subtype-selective opioid receptor antaGOnism may prove useful in the treatment of levodopa-related wearing-off in Parkinson#s disease (PD) [ ADR Type 1 ] | Non-subtype-selective opioid receptor antaGOnism in treatment of levodopa-induced motor complications in Parkinson's disease |
This panel provides information on drug category
| Toxicity | Source |
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