| Protein Name: | Bcl2-antaGOnist of cell death (Q92934) |
|---|---|
| Gene Name: | BAD |
| Description: | Bcl2 antaGOnist of cell death (BAD) (Bcl-2-binding component 6) (Bcl- XL/Bcl-2-associated death promoter) (Bcl-2-like 8 protein) |
| PDB ID: | 1G5J |
| Protein Family: | |
| Protein Category: | Cytosolic Protein |
This panel provides drug-protein interaction and their ADRs along with references
| Interacting Drugs | Toxicity | Mechanism | Reference |
|---|---|---|---|
| copper-zinc superoxide dismutase (SOD1) | Cell Death | The serine-threonine kinase Akt is activated by phosphorylation at serine-473@After phosphorylation@ activated Akt inactivates BAD or caspase-9 or other apoptogenic components@ thereby inhibiting cell death [ ADR Type 2 ] | Copper-zinc superoxide dismutase affects Akt activation after transient focal cerebral ischemia in mice |
| Paclitaxel | Apoptosis | Overexpression of Bcl-xL blocked various aspects of paclitaxel-mediated apoptosis@ including caspase-3 activation@ degradation of poly(ADP-ribose) polymerase (PARP)@ loss of mitochondrial membrane potential (Delta Psim)@ and release of cytochrome c. [ ADR Type 2 ] | Bryostatin 1 enhances paclitaxel-induced mitochondrial dysfunction and apoptosis in human leukemia cells (U937) ectopically expressing Bcl-xL Leukemia |
This panel provides information on drug category
| Toxicity | Source |
|---|