InAADR

Protein Information

Protein Name: Orphan nuclear receptor NR4A3 (Q92570)
Gene Name: NR4A3
Description: Orphan nuclear receptor NR4A3 (Nuclear hormone receptor NOR-1) (Neuron-derived orphan receptor 1) (Mitogen-induced nuclear orphan receptor)
PDB ID:
Protein Family:
Protein Category: Transcription Factor

This panel provides drug-protein interaction and their ADRs along with references

Interacting Drugs Toxicity Mechanism Reference
Mercaptopurine Atherogenesis The AF-1 domain of the orphan nuclear receptor NOR-1 mediates trans-activation@ coactivator recruitment@ and activation by the purine anti-metabolite 6-mercaptopurine@ which leads to atherogenesis [ ADR Type 2 ] The AF-1 domain of the orphan nuclear receptor NOR-1 mediates trans-activation, coactivator recruitment, and activation by the purine anti-metabolite 6-mercaptopurine
Mercaptopurine Cell Proliferation The AF-1 domain of the orphan nuclear receptor NOR-1 mediates trans-activation@ coactivator recruitment@ and activation by the purine anti-metabolite 6-mercaptopurine@ which leads to cell proliferation and differentiation [ ADR Type 2 ] The AF-1 domain of the orphan nuclear receptor NOR-1 mediates trans-activation, coactivator recruitment, and activation by the purine anti-metabolite 6-mercaptopurine
Mercaptopurine Chondrosarcomas The AF-1 domain of the orphan nuclear receptor NOR-1 mediates trans-activation@ coactivator recruitment@ and activation by the purine anti-metabolite 6-mercaptopurine@ which leads to chondrosarcomas [ ADR Type 2 ] The AF-1 domain of the orphan nuclear receptor NOR-1 mediates trans-activation, coactivator recruitment, and activation by the purine anti-metabolite 6-mercaptopurine
Mercaptopurine Inflammation The AF-1 domain of the orphan nuclear receptor NOR-1 mediates trans-activation@ coactivator recruitment@ and activation by the purine anti-metabolite 6-mercaptopurine@ which leads to inflammation. [ ADR Type 2 ] The AF-1 domain of the orphan nuclear receptor NOR-1 mediates trans-activation, coactivator recruitment, and activation by the purine anti-metabolite 6-mercaptopurine
Mercaptopurine Neurological Disorders The AF-1 domain of the orphan nuclear receptor NOR-1 mediates trans-activation@ coactivator recruitment@ and activation by the purine anti-metabolite 6-mercaptopurine@ which leads to neurological disorders [ ADR Type 2 ] The AF-1 domain of the orphan nuclear receptor NOR-1 mediates trans-activation, coactivator recruitment, and activation by the purine anti-metabolite 6-mercaptopurine
Mercaptopurine T-Cell Apoptosis The AF-1 domain of the orphan nuclear receptor NOR-1 mediates trans-activation@ coactivator recruitment@ and activation by the purine anti-metabolite 6-mercaptopurine@ which leads to T-cell apoptosis [ ADR Type 2 ] The AF-1 domain of the orphan nuclear receptor NOR-1 mediates trans-activation, coactivator recruitment, and activation by the purine anti-metabolite 6-mercaptopurine

This panel provides information on drug category

Toxicity Source

InAADR: Drug-Protein-ADRs database