| Protein Name: | p14(ARF) (Q8N726) |
|---|---|
| Gene Name: | CDKN2A |
| Description: | |
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This panel provides drug-protein interaction and their ADRs along with references
| Interacting Drugs | Toxicity | Mechanism | Reference |
|---|---|---|---|
| Zidovudine | Cellular Senescence | Inhibition of telomerase activity@progressive telomere shortening and increase p14(ARF) expression@elicit stabilization and reactivation of the tumor suppressor p53-dependent transcription@ increased expression of the cyclin-dependent kinase inhibitor p21(Waf1) and accumulation of p27(kip1)@ thereby inducing cellular senescence and tumor cell death [ ADR Type 1 ] | Persistent inhibition of telomerase reprograms adult T-cell leukemia to p53-dependent senescence |
This panel provides information on drug category
| Toxicity | Source |
|---|