| Protein Name: | Cell cycle-related kinase (Q8IZL9) |
|---|---|
| Gene Name: | CCRK |
| Description: | Cell cycle-related kinase (EC 2 7 11 22) (Cyclin-kinase-activating kinase p42) (CDK-activating kinase p42) (CAK-kinase p42) (Cyclin- dependent protein kinase H) |
| PDB ID: | |
| Protein Family: | |
| Protein Category: |
This panel provides drug-protein interaction and their ADRs along with references
| Interacting Drugs | Toxicity | Mechanism | Reference |
|---|---|---|---|
| Paclitaxel | Apoptosis | Expression of CDK4 seems to make the cells more sensitive to paclitaxel-induced apoptosis [ ADR Type 2 ] | CDK4 down-regulation induced by paclitaxel is associated with G1 arrest in gastric cancer cells |
| Paclitaxel | Cell Cycle Arrest | Paclitaxel-induced CDK4 down-regulation resulted in a cell cycle arrest at G1-S phase [ ADR Type 2 ] | CDK4 down-regulation induced by paclitaxel is associated with G1 arrest in gastric cancer cells |
This panel provides information on drug category
| Toxicity | Source |
|---|