| Protein Name: | Manganese-containing superoxide dismutase (Mn-SOD) (Q4ZJI1) |
|---|---|
| Gene Name: | GAST |
| Description: | Manganese-containing superoxide dismutase (Fragment) |
| PDB ID: | |
| Protein Family: | |
| Protein Category: |
This panel provides drug-protein interaction and their ADRs along with references
| Interacting Drugs | Toxicity | Mechanism | Reference |
|---|---|---|---|
| Paclitaxel | Apoptosis | Paclitaxel-induced apoptosis of breast cancer cells. Constitutive activation of NF-kappaB leads to overexpression of the anti-apoptotic genes c-inhibitor of apoptosis 2 (c-IAP2) and manganese superoxide dismutase (Mn-SOD) in breast cancer cells. [ ADR Type 2 ] | Paclitaxel sensitivity of breast cancer cells with constitutively active NF-kappaB is enhanced by IkappaBalpha super-repressor |
| Paclitaxel | Apoptosis Of Breast Cancer Cells | Constitutive activation of NF-kappaB leads to overexpression of the anti-apoptotic genes c-inhibitor of apoptosis 2 (c-IAP2) and manganese superoxide dismutase (Mn-SOD) in breast cancer cells@which increase paclitaxel-induced apoptosis of breast cancer cells [ ADR Type 2 ] | Paclitaxel sensitivity of breast cancer cells with constitutively active NF-kappaB is enhanced by IkappaBalpha super-repressor |
This panel provides information on drug category
| Toxicity | Source |
|---|