| Protein Name: | Glutamate pyruvate transaminase (Q28DB5) |
|---|---|
| Gene Name: | Not Available |
| Description: | |
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This panel provides drug-protein interaction and their ADRs along with references
| Interacting Drugs | Toxicity | Mechanism | Reference |
|---|---|---|---|
| Acetaminophen | Hyperglycemia | Fasted animals showed a dramatic INCREASE in susceptibility to acetaminophen-induced hepatotoxicity as measured by increased SGPT levels@SUGGESTING Acetaminophen-INDUCED hepatic glycogen depletion and hyperglycemia in mice [ ADR Type 2 ] | Acetaminophen-induced hepatic glycogen depletion and hyperglycemia in mice |
| Chlorpromazine | Hepatotoxicity | A toxic dose of the drug (LD20)produced elevated serum glutamate-pyruvate transaminase and lactate dehydrogenase activities 20-24 hr after drug administration@which leads to hepatotoxicity of acetaminophen in neonatal and young rats [ ADR Type 1 ] | Hepatotoxicity of acetaminophen in neonatal and young rats I Age-related changes in susceptibility |
| Lidocaine | Fever | The elevation of glutamic oxalacetic transaminase (GOT)@ glutamic pyruvic transaminase (GPT)@ alkaline phosphatase (ALP)@ and gamma glutamyltrans peptidase (gamma-GTP)@ C reactive protein (CRP)@ and blood sedimentation rate (BSR)@suggest strongly that 0.5% lidocaine induced fever. [ ADR Type 2 ] | Unknown fever and abnormal liver functions after repeated epidural blocks with lidocaine for management of herpes zoster pain |
| Lidocaine | Hepatitis | The elevation of glutamic oxalacetic transaminase (GOT)@ glutamic pyruvic transaminase (GPT)@ alkaline phosphatase (ALP)@ and gamma glutamyltrans peptidase (gamma-GTP)@ C reactive protein (CRP)@ and blood sedimentation rate (BSR)@suggest strongly that 0.5% lidocaine induced hepatitis. [ ADR Type 2 ] | Unknown fever and abnormal liver functions after repeated epidural blocks with lidocaine for management of herpes zoster pain |
| Methotrexate | Increase In The Death Rate | If methotrexate is applied@ there is an increase in the death rate@ as well as in glutamate-oxaloacetate transaminase (GOT) and glutamate-pyruvate transaminase (GPT) activities [ ADR Type 2 ] | Nicotinamide and methionine reduce the liver toxic effect of methotrexate |
This panel provides information on drug category
| Toxicity | Source |
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