| Protein Name: | Eukaryotic translation initiation factor 4E-binding protein (Q13541) |
|---|---|
| Gene Name: | EIF4EBP1 |
| Description: | Eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) (eIF4E-binding protein 1) (Phosphorylated heat- and acid-stable protein regulated by insulin 1) (PHAS-I) |
| PDB ID: | 1EJ4 |
| Protein Family: | |
| Protein Category: |
This panel provides drug-protein interaction and their ADRs along with references
| Interacting Drugs | Toxicity | Mechanism | Reference |
|---|---|---|---|
| Dehydrated Alcohol | Impairs Insulin | EtOH altered the distribution of eukaryotic initiation factor (eIF)4E@ as evidenced by a decreased amount of active eIF4E. eIF4G complex@ an increased amount of inactive eIF4E-binding protein (BP)1 complex@ and decreased 4E-BP1 phosphorylation@which impairs insulin and IGF-I stimulation of S6K1. [ ADR Type 2 ] | Alcohol impairs insulin and IGF-I stimulation of S6K1 but not 4E-BP1 in skeletal muscle |
This panel provides information on drug category
| Toxicity | Source |
|---|