| Protein Name: | Sterol regulatory element-binding protein 2 (Q12772) |
|---|---|
| Gene Name: | SREBF2 |
| Description: | Sterol regulatory element-binding protein 2 (SREBP-2) (Sterol regulatory element-binding transcription factor 2) |
| PDB ID: | 1UKL |
| Protein Family: | |
| Protein Category: |
This panel provides drug-protein interaction and their ADRs along with references
| Interacting Drugs | Toxicity | Mechanism | Reference |
|---|---|---|---|
| Ritonavir | Abnormality Of Hepatic Steatosis | Abnormality of hepatic steatosis after Ritonavir treatment is due to ritonavir-induced accumulation of the activated forms of sterol regulatory binding protein (SREBP)-2 in the nucleus of liver and adipose@ resulting in elevated expression of lipid metabolism genes [ ADR Type 1 ] | HIV protease inhibitor induces fatty acid and sterol biosynthesis in liver and adipose tissues due to the accumulation of activated sterol regulatory element-binding proteins in the nucleus |
| Ritonavir | Abnormality Of Hepatomegaly | Abnormality of hepatomegaly after Ritonavir treatment is due to ritonavir-induced accumulation of the activated forms of sterol regulatory binding protein (SREBP)-2 in the nucleus of liver and adipose@ resulting in elevated expression of lipid metabolism genes [ ADR Type 1 ] | HIV protease inhibitor induces fatty acid and sterol biosynthesis in liver and adipose tissues due to the accumulation of activated sterol regulatory element-binding proteins in the nucleus |
This panel provides information on drug category
| Toxicity | Source |
|---|