| Protein Name: | sulfonylurea receptors (Q09429) |
|---|---|
| Gene Name: | Abcc8 |
| Description: | |
| PDB ID: | |
| Protein Family: | |
| Protein Category: |
This panel provides drug-protein interaction and their ADRs along with references
| Interacting Drugs | Toxicity | Mechanism | Reference |
|---|---|---|---|
| Glimepiride | Blood Sugar Lowering Effect | Drastic decrease of the dissociation rate constant of glimepiride leads to acute blood sugar lowering efficacy. [ ADR Type 1 ] | Differential interaction of glimepiride and glibenclamide with the beta-cell sulfonylurea receptor I Binding characteristics |
| Glyburide | Obesity-Prone | Glucose may affect the firing of glucose-responsive neurons by indirectly altering KATP channel function via its effects on low-affinity cell body SUR. [ ADR Type 2 ] | In vivo and in vitro regulation of [3H]glyburide binding to brain sulfonylurea receptors in obesity-prone and resistant rats by glucose |
| Tolbutamide | Myelosuppression | Myelosuppression [ ADR Type 1 ] | The pharmacogenetics of beta2-adrenergic receptors: relevance to asthma |
This panel provides information on drug category
| Toxicity | Source |
|---|