| Protein Name: | BAX protein (Q07815) |
|---|---|
| Gene Name: | BAX |
| Description: | BAX protein, cytoplasmic isoform gamma |
| PDB ID: | 1F16 |
| Protein Family: | |
| Protein Category: |
This panel provides drug-protein interaction and their ADRs along with references
| Interacting Drugs | Toxicity | Mechanism | Reference |
|---|---|---|---|
| Arsenic trioxide | Apoptosis | Arsenic trioxide-induced death of neuroblastoma cells involves activation of BAX and does not require p53@SO activation of Bax is an important event in As(2)O(3)-induced cell death. [ ADR Type 2 ] | Arsenic trioxide-induced death of neuroblastoma cells involves activation of Bax and does not require p53 |
| interferon gamma | Apoptosis | NO/ONOO(-)-mediated apoptosis was associated with increased expression of Bax with no change in Bcl-2 mRNA abundance [ ADR Type 2 ] | Parsing the effects of nitric oxide, S-nitrosothiols, and peroxynitrite on inducible nitric oxide synthase-dependent cardiac myocyte apoptosis |
| Lovastatin | Apoptosis | Since immunoelectron microscopy showed translocation of Bax to the mitochondria in lovastatin-treated cells@ lovastatin-induced apoptosis may@ therefore@ ultimately dependent on Bax induction of cytochrome c release. [ ADR Type 5 ] | Lovastatin inhibits tumor growth and lung metastasis in mouse mammary carcinoma model: a p53-independent mitochondrial-mediated apoptotic mechanism |
This panel provides information on drug category
| Toxicity | Source |
|---|