| Protein Name: | iNOS (inducible nitric oxide synthase) (Q06518) |
|---|---|
| Gene Name: | Not Available |
| Description: | |
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This panel provides drug-protein interaction and their ADRs along with references
| Interacting Drugs | Toxicity | Mechanism | Reference |
|---|---|---|---|
| Amphotericin B | Neurotoxicity | The activation of transcription factor NF-kappaB was apparently required for AMB-induced iNOS mRNA expression@ as the latter was abolished by NF-kappaB inhibitors@which might be at least partly responsible for AMB neurotoxicity [ ADR Type 2 ] | Amphotericin B potentiates the activation of inducible nitric oxide synthase and causes nitric oxide-dependent mitochondrial dysfunction in cytokine-treated rodent |
This panel provides information on drug category
| Toxicity | Source |
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