| Protein Name: | Purine nucleoside phosphorylase (P00491) |
|---|---|
| Gene Name: | NP |
| Description: | Purine nucleoside phosphorylase (EC 2 4 2 1) (Inosine phosphorylase) (PNP) |
| PDB ID: | 1M73 |
| Protein Family: | |
| Protein Category: | Enzyme |
This panel provides drug-protein interaction and their ADRs along with references
| Interacting Drugs | Toxicity | Mechanism | Reference |
|---|---|---|---|
| Adenosine, deoxyadenosine and deoxyguanosine | Thymocyte Deletion | The DNA cleavage and subsequent cell lysis might be related to the selective thymocyte deletion observed in patients with purine nucleoside phosphorylase deficiency [ ADR Type 2 3 ] | Adenosine, deoxyadenosine, and deoxyguanosine induce DNA cleavage in mouse thymocytes |
| Azathioprine | Bone Marrow Toxicity | All 3 patients with severe AZA-related bone marrow toxicity had abnormal nucleoside phosphorylase activities [ ADR Type 2 ] | A Azathioprine-related bone marrow toxicity and low activities of purine enzymes in patients with rheumatoid arthritis |
This panel provides information on drug category
| Toxicity | Source |
|---|