| Protein Name: | Poly [ADP-ribose] polymerase (P09874) |
|---|---|
| Gene Name: | PARP1 |
| Description: | Poly [ADP-ribose] polymerase 1 (EC 24230) (PARP-1) (ADPRT) (NAD(+) ADP-ribosyltransferase 1) (Poly[ADP-ribose] synthetase 1) |
| PDB ID: | 1UK0 |
| Protein Family: | |
| Protein Category: | Enzyme |
| Protein Name: | Poly [ADP-ribose] polymerase (Q9ZP54) |
| Gene Name: | Not Available |
| Description: | Poly [ADP-ribose] polymerase 1 (EC 2 4 2 30) (PARP-1) (ADPRT 1) (NAD(+) ADP-ribosyltransferase 1) (Poly[ADP-ribose] synthetase 1) |
| PDB ID: | 1V9X |
| Protein Family: | |
| Protein Category: |
This panel provides drug-protein interaction and their ADRs along with references
| Interacting Drugs | Toxicity | Mechanism | Reference |
|---|---|---|---|
| Dexamethasone | Apoptosis | Dex induce poly (ADP ribose) polymerase (PARP) cleavage@ a signature event of apoptosis. [ ADR Type 2 ] | Dexamethasone induces apoptosis of multiple myeloma cells in a JNK/SAP kinase independent mechanism |
| Paclitaxel | Apoptosis | Overexpression of Bcl-xL blocked various aspects of paclitaxel-mediated apoptosis by caspase-3 activation. [ ADR Type 2 ] | Bryostatin 1 enhances paclitaxel-induced mitochondrial dysfunction and apoptosis in human leukemia cells (U937) ectopically expressing Bcl-xL Leukemia |
| Paclitaxel | Mitochondrial Defects | Overexpression of Bcl-xL blocked various aspects of paclitaxel-mediated mitochondrial dysfunction by degradation of poly(ADP-ribose) polymerase (PARP) [ ADR Type 2 ] | Bryostatin 1 enhances paclitaxel-induced mitochondrial dysfunction and apoptosis in human leukemia cells (U937) ectopically expressing Bcl-xL Leukemia |
| Uracil Mustard | Apoptosis | A significant correlation (r = 0.94) was observed between the compounds# ability to inhibit poly(ADP-ribose) polymerase (PADPRP) and the compounds# ability to reduce HD- induced cell death@ suggesting that poly(ADP-ribose) polymerase (PADPRP) plays a role in HD-induced cell death. [ ADR Type 1 ] | Effects of specific inhibitors of cellular functions on sulfur mustard-induced cell death |
This panel provides information on drug category
| Toxicity | Source |
|---|