| Protein Name: | P21 protein (P78460) |
|---|---|
| Gene Name: | Not Available |
| Description: | P21 protein (Fragment) |
| PDB ID: | |
| Protein Family: | |
| Protein Category: |
This panel provides drug-protein interaction and their ADRs along with references
| Interacting Drugs | Toxicity | Mechanism | Reference |
|---|---|---|---|
| Digoxin | Oncogenesis | Digoxin induced alteration in intracellular calcium/magnesium ratios and low ubiquinone levels can lead to a mitochondrial dysfunction resulting in increased free radical generation and reduced scavenging & caspase-3 activation producing a P21 defect contributing to oncogenesis. [ ADR Type 2 ] | Hypothalamic digoxin mediated model for oncogenesis |
| Indomethacin | Arrests Endothelial Cell Proliferation | Indomethacin significantly inhibited basal and bFGF-stimulated endothelial cell proliferation@which is correlated significantly with reduced cyclin D1 and increased p21 protein expression@suggestting that indomethacin arrests endothelial cell proliferation essential for angiogenesis by modulating cell cycle protein levels. [ ADR Type 2 ] | Indomethacin inhibits endothelial cell proliferation by suppressing cell cycle proteins and PRB phosphorylation: a key to its antiangiogenic action? |
| Zidovudine | Cellular Senescence | Inhibition of telomerase activity@progressive telomere shortening and increase p14(ARF) expression@elicit stabilization and reactivation of the tumor suppressor p53-dependent transcription@ increased expression of the cyclin-dependent kinase inhibitor p21(Waf1) and accumulation of p27(kip1)@ thereby inducing cellular senescence and tumor cell death [ ADR Type 1 ] | Persistent inhibition of telomerase reprograms adult T-cell leukemia to p53-dependent senescence |
| Zidovudine | Tumor Cell Death | Inhibition of telomerase activity@progressive telomere shortening and increase p14(ARF) expression@elicit stabilization and reactivation of the tumor suppressor p53-dependent transcription@ increased expression of the cyclin-dependent kinase inhibitor p21(Waf1) and accumulation of p27(kip1)@ thereby inducing cellular senescence and tumor cell death [ ADR Type 1 ] | Persistent inhibition of telomerase reprograms adult T-cell leukemia to p53-dependent senescence |
This panel provides information on drug category
| Toxicity | Source |
|---|---|
| Apoptosis | Histone deacetylase inhibitor LAQ824 both lowers expression and promotes proteasomal degradation of Bcr-Abl and induces apoptosis |