| Protein Name: | UDP-glucuronosyltransferase 2B15 precursor (P54855) |
|---|---|
| Gene Name: | UGT2B15 |
| Description: | UDP-glucuronosyltransferase 2B15 precursor (EC 24117) (UDPGT) (UDPGTh-3) (HLUG4) |
| PDB ID: | |
| Protein Family: | |
| Protein Category: | Enzyme |
This panel provides drug-protein interaction and their ADRs along with references
| Interacting Drugs | Toxicity | Mechanism | Reference |
|---|---|---|---|
| Acetaminophen | Toxicity In Human Hepatocytes | The inhibition of APAP glucuronidation by phenobarbital leads to an increase in APAP-mediated toxicity in human hepatocytes; The toxicity to hepatocytes was further increased by coadministering APAP with phenytoin and phenobarbital;This synergistic increase in toxicity is postulated to be due to inhibition of UGTs. [ ADR Type 4 ] | Kinetics of acetaminophen glucuronidation by UDP-glucuronosyltransferases 1A1, 1A6, 1A9 and 2B15 Potential implications in acetaminophen-induced hepatotoxicity |
This panel provides information on drug category
| Toxicity | Source |
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