InAADR

Protein Information

Protein Name: Potassium voltage-gated channel subfamily KQT member 1 (P51787)
Gene Name: KCNQ1
Description:
PDB ID: 3BJ4
Protein Family: PF00520
Protein Category: Ion Channels

This panel provides drug-protein interaction and their ADRs along with references

Interacting Drugs Toxicity Mechanism Reference
Amiodarone Sudden Cardiac Death Sudden cardiac death due to long-QT syndrome [ ADR Type 2 ] Genetic and molecular basis of cardiac arrhythmias: impact on clinical management parts I and II
Atenolol Sudden Cardiac Death Sudden cardiac death due to long-QT syndrome [ ADR Type 2 ] Genetic and molecular basis of cardiac arrhythmias: impact on clinical management parts I and II
Cisapride Torsade De Pointes Increased risk of drug-induced torsade de pointes [ ADR Type 2 ] MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia
Clarithromycin Torsade De Pointes Increased risk of drug-induced torsade de pointes. [ ADR Type 2 ] MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia
Covera Sudden Cardiac Death Sudden cardiac death due to long-QT syndrome [ ADR Type 2 ] Genetic and molecular basis of cardiac arrhythmias: impact on clinical management parts I and II
Diltiazem Sudden Cardiac Death Sudden cardiac death due to long-QT syndrome [ ADR Type 2 ] Genetic and molecular basis of cardiac arrhythmias: impact on clinical management parts I and II
Erythromycin Torsade De Pointes Increased risk of drug-induced torsade de pointes. [ ADR Type 2 ] MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia
Flecainide Sudden Cardiac Death Sudden cardiac death due to long-QT syndrome [ ADR Type 2 ] Genetic and molecular basis of cardiac arrhythmias: impact on clinical management parts I and II
Hydrochlorothiazide Sudden Cardiac Death Sudden cardiac death due to long-QT syndrome [ ADR Type 2 ] Genetic and molecular basis of cardiac arrhythmias: impact on clinical management parts I and II
Mexiletine Sudden Cardiac Death Sudden cardiac death due to long-QT syndrome [ ADR Type 2 ] Genetic and molecular basis of cardiac arrhythmias: impact on clinical management parts I and II
Moricizine Sudden Cardiac Death Sudden cardiac death due to long-QT syndrome [ ADR Type 2 ] Genetic and molecular basis of cardiac arrhythmias: impact on clinical management parts I and II
Pacerone Sudden Cardiac Death Sudden cardiac death due to long-QT syndrome [ ADR Type 2 ] Genetic and molecular basis of cardiac arrhythmias: impact on clinical management parts I and II
Procainamide Sudden Cardiac Death Sudden cardiac death due to long-QT syndrome [ ADR Type 2 ] Genetic and molecular basis of cardiac arrhythmias: impact on clinical management parts I and II
Pronestyl Sudden Cardiac Death Sudden cardiac death due to long-QT syndrome [ ADR Type 2 ] Genetic and molecular basis of cardiac arrhythmias: impact on clinical management parts I and II
Propafenone Sudden Cardiac Death Sudden cardiac death due to long-QT syndrome [ ADR Type 2 ] Genetic and molecular basis of cardiac arrhythmias: impact on clinical management parts I and II
Propranolol Sudden Cardiac Death Sudden cardiac death due to long-QT syndrome [ ADR Type 2 ] Genetic and molecular basis of cardiac arrhythmias: impact on clinical management parts I and II
Quinidine Sudden Cardiac Death Sudden cardiac death due to long-QT syndrome [ ADR Type 2 ] Genetic and molecular basis of cardiac arrhythmias: impact on clinical management parts I and II
Quinidine Torsade De Pointes Increased risk of drug-induced torsade de pointes. [ ADR Type 2 ] MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia
Sotalol Sudden Cardiac Death Sudden cardiac death due to long-QT syndrome [ ADR Type 2 ] Genetic and molecular basis of cardiac arrhythmias: impact on clinical management parts I and II
Terfenadine Palpitations Not Available Large-scale prediction and testing of drug activity on side-effect targets
Terfenadine Sudden Cardiac Death Sudden cardiac death due to long-QT syndrome [ ADR Type 2 ] Genetic and molecular basis of cardiac arrhythmias: impact on clinical management parts I and II
Terfenadine Torsade De Pointes Increased risk of drug-induced torsade de pointes [ ADR Type 2 ] MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia
Tikosyn Sudden Cardiac Death Sudden cardiac death due to long-QT syndrome [ ADR Type 2 ] Genetic and molecular basis of cardiac arrhythmias: impact on clinical management parts I and II
Tocainide Sudden Cardiac Death Sudden cardiac death due to long-QT syndrome [ ADR Type 2 ] Genetic and molecular basis of cardiac arrhythmias: impact on clinical management parts I and II
Toprol XL Sudden Cardiac Death Sudden cardiac death due to long-QT syndrome [ ADR Type 2 ] Genetic and molecular basis of cardiac arrhythmias: impact on clinical management parts I and II
verapamil Sudden Cardiac Death Sudden cardiac death due to long-QT syndrome [ ADR Type 2 ] Genetic and molecular basis of cardiac arrhythmias: impact on clinical management parts I and II

InAADR: Drug-Protein-ADRs database