| Protein Name: | Mitogen-activated protein kinase p54-JNK2 (P49186) |
|---|---|
| Gene Name: | Not Available |
| Description: | Mitogen-activated protein kinase 9 (EC 2 7 11 24) (Stress-activated protein kinase JNK2) (c-Jun N-terminal kinase 2) (SAPK-alpha) (p54- alpha) |
| PDB ID: | |
| Protein Family: | |
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This panel provides drug-protein interaction and their ADRs along with references
| Interacting Drugs | Toxicity | Mechanism | Reference |
|---|---|---|---|
| Etoposide | Cell Death | Induction of apoptotic cell death and DNA damage by treatment of U937 cells with etoposide (100 microM) was associated with phosphorylation and activation of the c-Jun NH(2)-terminal kinase (JNK1) SAPK enzymes p46 and p54-JNK2 and transient increases in expression of the transcription factor c-Jun@ a primary JNK substrate [ ADR Type 2 ] | Evidence that the apoptotic actions of etoposide are independent of c-Jun/activating protein-1-mediated transregulation |
| Etoposide | Dna Damage | Induction of apoptotic cell death and DNA damage by treatment of U937 cells with etoposide (100 microM) was associated with phosphorylation and activation of the c-Jun NH(2)-terminal kinase (JNK1) SAPK enzymes p46 and p54-JNK2 and transient increases in expression of the transcription factor c-Jun@ a primary JNK substrate [ ADR Type 2 ] | Evidence that the apoptotic actions of etoposide are independent of c-Jun/activating protein-1-mediated transregulation |
This panel provides information on drug category
| Toxicity | Source |
|---|