InAADR: Drug-Protein-ADRs database

InAADR

Enter Protein Name or Uniprot ID:

Protein Information

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Protein Name:	Peroxisome proliferator-activated receptor gamma (P37231)
Gene Name:	PPARG
Description:
PDB ID:	1FM6
Protein Family:	PF00104, PS00031
Protein Category:	Epigenetic regulator
Transcription Factor

Drug-Protein Interaction
Adverse Drug Reactions

This panel provides drug-protein interaction and their ADRs along with references

Interacting Drugs	Toxicity	Mechanism	Reference
HIV-1 protease-inhibitor	Impaired Fat Storage And Lipid Release	HIV-1 protease inhibitor-induced peripheral lipodystrophy is a result of impaired CRABP1-mediated cis-9-retinoic acid stimulation of RXR:PPAR-?@ resulting in reduced differentiation and increased apoptosis of peripheral adipocytes@ with impaired fat storage and lipid release. [ ADR Type 2 3 ]	Pathogenesis of HIV-1-protease inhibitor-associated peripheral lipodystrophy, hyperlipidaemia, and insulin resistance

This panel provides information on drug category

Toxicity	Source
Dyspepsia	Large-scale prediction and testing of drug activity on side-effect targets
Lipodystrophy	New PPARG mutation leads to lipodystrophy and loss of protein function that is partially restored by a synthetic ligand
Obesity	The Pro12Ala variant at the peroxisome proliferator-activated receptor gamma gene and change in obesity-related traits in the Diabetes Prevention Program
Type 2 Diabetes	Interference with PPAR gamma function in smooth muscle causes vascular dysfunction and hypertension

InAADR: Drug-Protein-ADRs database