| Protein Name: | Sterol regulatory element-binding protein 1 (P36956) |
|---|---|
| Gene Name: | SREBF1 |
| Description: | Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1) |
| PDB ID: | 1AM9 |
| Protein Family: | |
| Protein Category: |
This panel provides drug-protein interaction and their ADRs along with references
| Interacting Drugs | Toxicity | Mechanism | Reference |
|---|---|---|---|
| Ritonavir | Abnormality Of Hepatic Steatosis | Abnormality of hepatic steatosis after Ritonavir treatment is due to ritonavir-induced accumulation of the activated forms of sterol regulatory binding protein (SREBP)-1 in the nucleus of liver and adipose@ resulting in elevated expression of lipid metabolism genes [ ADR Type 1 ] | HIV protease inhibitor induces fatty acid and sterol biosynthesis in liver and adipose tissues due to the accumulation of activated sterol regulatory element-binding proteins in the nucleus |
| Ritonavir | Abnormality Of Hepatomegaly | Abnormality of hepatomegaly after Ritonavir treatment is due to ritonavir-induced accumulation of the activated forms of sterol regulatory binding protein (SREBP)-1 in the nucleus of liver and adipose@ resulting in elevated expression of lipid metabolism genes [ ADR Type 1 ] | HIV protease inhibitor induces fatty acid and sterol biosynthesis in liver and adipose tissues due to the accumulation of activated sterol regulatory element-binding proteins in the nucleus |
| Troglitazone | Obesity | Hepatic SREBP-1 mRNA was 2.4 times higher than in lean +/+ controls@ primarily because of increased SREBP-1c expression@which may play a role in the ectopic lipogenesis and lipotoxicity complicating obesity in Zucker diabetic fatty rats. [ ADR Type 1 ] | Leptin, troglitazone, and the expression of sterol regulatory element binding proteins in liver and pancreatic islets |
This panel provides information on drug category
| Toxicity | Source |
|---|