InAADR

Protein Information

Protein Name: Cystathionine beta-synthase (P35520)
Gene Name: CBS
Description: Cystathionine beta-synthase (EC 42122) (Serine sulfhydrase) (Beta- thionase)
PDB ID: 1JBQ
Protein Family:
Protein Category:

This panel provides drug-protein interaction and their ADRs along with references

Interacting Drugs Toxicity Mechanism Reference
Methionine Platelet Aggregation Genetic defects such as cystathionine beta-synthase or methylene-tetrahydrofolate reductase may contribute to increasing plasma homocysteine levels@which could lead to the pathogenesis of Hcy(formed by demethylation of methionine)-induced vascular damage may be multifactorial@ including direct Hcy damage to the endothelium@ stimulation of proliferation of smooth muscle cells@ enhanced low-density lipoprotein peroxidation@ increase of platelet aggregation@ and effects on the coagulation system. [ ADR Type 3 ] Hyperhomocysteinemia: atherothrombosis and neurotoxicity

This panel provides information on drug category

Toxicity Source

InAADR: Drug-Protein-ADRs database