InAADR

Protein Information

Protein Name: Multidrug resistance-associated protein (P33527)
Gene Name: ABCC1
Description: Multidrug resistance-associated protein 1 (ATP-binding cassette sub- family C member 1) (Leukotriene C(4) transporter) (LTC4 transporter)
PDB ID: 2CBZ
Protein Family:
Protein Category: Transporters

This panel provides drug-protein interaction and their ADRs along with references

Interacting Drugs Toxicity Mechanism Reference
Indomethacin Cytotoxicity Indomethacin inhibites the activity of MDR-associated protein (MRP)@ thus increases the Cytotoxicity of doxorubicin [ ADR Type 4 ] P-glycoprotein and multidrug resistance-associated protein mediate specific patterns of multidrug resistance in malignant glioma cell lines, but not in primary glioma cells
Ivermectin Cytotoxicity Ivermectin efficiently inhibites the fully activated ATPase of MRP1 with respective IC50 values of 9 ? 4?M@ thus increases the Cytotoxicity of benzbromarone. [ ADR Type 4 ] P-glycoprotein and multidrug resistance-associated protein mediate specific patterns of multidrug resistance in malignant glioma cell lines, but not in primary glioma cells
Probenecid Cytotoxicity probenecid inhibites the activity of MDR-associated protein (MRP)@ thus increases the Cytotoxicity of doxorubicin [ ADR Type 4 ] P-glycoprotein and multidrug resistance-associated protein mediate specific patterns of multidrug resistance in malignant glioma cell lines, but not in primary glioma cells

This panel provides information on drug category

Toxicity Source

InAADR: Drug-Protein-ADRs database