| Protein Name: | RAC-alpha serine/threonine-protein kinase (P31749) |
|---|---|
| Gene Name: | AKT1 |
| Description: | RAC-alpha serine/threonine-protein kinase (EC 2 7 11 1) (RAC-PK-alpha) (Protein kinase B) (PKB) (C-AKT) |
| PDB ID: | 1H10 |
| Protein Family: | |
| Protein Category: | Cytosolic Protein | Enzyme |
This panel provides drug-protein interaction and their ADRs along with references
| Interacting Drugs | Toxicity | Mechanism | Reference |
|---|---|---|---|
| copper-zinc superoxide dismutase (SOD1) | Cell Death | The serine-threonine kinase Akt is activated by phosphorylation at serine-473 After phosphorylation@ activated Akt inactivates BAD or caspase-9 or other apoptogenic components@ thereby inhibiting cell death [ ADR Type 2 ] | Copper-zinc superoxide dismutase affects Akt activation after transient focal cerebral ischemia in mice |
| Mannitol | Apoptosis | One of the pathways of mannitol-mediated apoptosis is through the degradation of FAK and Akt and that IGF-I protects the cells from apoptosis by blocking the activation of caspases@ which may be responsible for the loss of FAK and Akt [ ADR Type 2 ] | Insulin-like growth factor I prevents mannitol-induced degradation of focal adhesion kinase and Akt |
This panel provides information on drug category
| Toxicity | Source |
|---|