This panel provides drug-protein interaction and their ADRs along with references
| Interacting Drugs |
Toxicity |
Mechanism |
Reference |
|---|
| Alprazolam | Anterograde Amnesia | Anterograde amnesia produced by alprazolam may be mediated through the activation of benzodiazepine receptors. [ ADR Type 1 ] | Possible mechanism of alprazolam-induced amnesia in mice
|
| CL 218872 | Impair Learning | CL 218@872@ a selective ligand for the benzodiazepine omega 1 receptor subtype@ impairs place learning in the Morris water maze [ ADR Type 2 3 ] | Like diazepam, CL 218,872, a selective ligand for the benzodiazepine omega 1 receptor subtype, impairs place learning in the Morris water maze
|
| Diazepam | Amnesia | Coactivation of both the omega 1 and omega 2 receptor subtypes with diazepam produce amnesia [ ADR Type 2 3 ] | Like diazepam, CL 218,872, a selective ligand for the benzodiazepine omega 1 receptor subtype, impairs place learning in the Morris water maze
|
| Diazepam | Anxiolysis | Coactivation of both the omega 1 and omega 2 receptor subtypes with diazepam produce anxiolysis [ ADR Type 2 3 ] | Like diazepam, CL 218,872, a selective ligand for the benzodiazepine omega 1 receptor subtype, impairs place learning in the Morris water maze
|
| Diazepam | Sedation | Coactivation of both the omega 1 and omega 2 receptor subtypes with diazepam produce sedation@ anxiolysis@ and amnesia [ ADR Type 2 3 ] | Like diazepam, CL 218,872, a selective ligand for the benzodiazepine omega 1 receptor subtype, impairs place learning in the Morris water maze
|
This panel provides information on drug category